产品名称 小鼠5-α还原酶(5α-reductase)ELISA试剂盒试剂盒 产品规格 48T/96T 有效成分含量 99 保质期 6个月 储存条件 避光防潮 用途范围 实验室 是否进口 否 产品类型 生物试剂 贮藏 2-8℃冷藏 产地 上海 注意事项 使用前充分摇匀 检测范围 1-120pg/mL 特异性 不与其它可溶性结构类似物交叉...
5α-还原酶(5α-Reductase)是一种酶,可以催化睾酮转化为二氢睾酮(DHT),这是一种更为活性的男性荷尔蒙。它还有多种亚型,其中最重要的亚型是5α-还原酶类型2,主要由前列腺和睾丸组织产生。 DHT是一种能够结合雄激素受体和影响雄性特征的激素,主要在睾丸、前列腺和其他外周组织中发挥作用,具有重要的生物学功能,如...
5-a-Reductase inhibitors in models of psychosis M Bortolato et al po0.001; main effect of treatment: F(1, 30) ¼ 15.14, po0.001; interaction treatment  pretreatment: F(1, 30) ¼ 6.26, po0.01; ANOVA) (Figure 1a). Post-hoc comparisons revealed that both 60 and 100 mg/kg FIN...
度他雄胺/盐酸坦洛新: 一种5α-reductase抑制剂、α1A-AR拮抗剂药物,由Hanmi Pharmaceutical Co., Ltd. (Hanmi Pharmaceutical Co., Ltd.)公司最早进行研发,目前全球最高研发状态为批准上市,作用机制: 5α-reductase抑制剂(类固醇5α还原酶抑制剂),α1A-AR拮抗剂(肾上腺
15-a还原酶抑制剂(度他雄胺)与5-a还原酶(5-alphareductaseinhibitorand5-alphareductase)-a还原酶的分布研究发现人体中5a还原酶有两种同工酶,即5a还原酶1和5a还原酶2。5a还原酶1存在于身体任何有5a还原酶表达的部位,包括皮肤、肝脏和前列腺等。5a还原酶2主要存在于前列腺及其他生殖组织等。研究发现,两种同工...
5α-reductases, a unique family of enzymes with a wide host of substrates and tissue distributions, play a key role in the metabolism of androgens, progestins, mineralocorticoids and glucocorticoids. These enzymes are the rate-limiting step in the synthesis of a host of neurosteroids, which are...
The condition of 5-alpha-reductase type 2deficiency (5-ARD) is an inherited disorderresulting in the inability to converttestosterone to dihydrotestosterone(DHT).This disorder was previously termed asfamilial incomplete male pseudohermaphroditism type2, pseudovaginal perineoscrotal hypospadias.Clinical manife...
5α-Reductase (5αR) 2 deficiency 46 XY pseudohermaphrodites, who are born with female or ambiguous genitalia and are largely raised as girls, often dramatically turn around toward puberty to become muscular men with small genitalia and minimal tendency for body hair growth, all probably due to...
5-Alpha reductase is an enzyme responsible for the conversion of testosterone to dihydrotestosterone. This key enzyme is responsible for triggering masculinization of the male external genitalia. Discovery of 5-alpha reductase deficiency as a syndrome of disordered male sexual development led to our mol...
To clarify the possible interference of the 5α-reductase inhibitor dutasteride with α-adrenergic blockers, whose action is mainly mediated by α1A-adrenergic receptor. Male rats were divided into dutasteride and vehicle-treated groups. The drug treatment group was treated with oral dutasteride 0.5...