(2015) Human sperm molecular anat- omy: the enzyme 5α-reductase (SRD5A) is present in the sperm and may be involved in the varicocele-related infer- tility. Histochem Cell Biol 143: 421-429.Aquila S,Montanaro D,Guido C,et al. Human sperm molecu- lar anatomy: The enzyme 5α-...
5-hydroxy-3-methylglutaryl-coenzyme A reductase,HMG-CoA reductase- a liver enzyme that is responsible for producing cholesterol enzyme- any of several complex proteins that are produced by cells and act as catalysts in specific biochemical reactions ...
aelevated levels of both type I and II 5a-reductase enzyme 类型I和II的高的水平5a还原酶酵素 [translate] 英语翻译 日语翻译 韩语翻译 德语翻译 法语翻译 俄语翻译 阿拉伯语翻译 西班牙语翻译 葡萄牙语翻译 意大利语翻译 荷兰语翻译 瑞典语翻译 希腊语翻译 51La ...
17-N, N-diethylcarbamoyl-4-methyl-4-aza-5-an-drostan-3-one (4-MA) inhibits 5-reductase activity in cultured human genital skin fibroblasts. Enzyme kinetic studies analyzed by Eadie-Hofstee plots demonstrated that 4-MA is a competitive inhibitor, with an apparent Ki of 15 nM. 4-MA had ...
The DNA sequence encoding steroid 5 alpha-reductase 2, the major active isozyme of human genital tissue, is disclosed herein, in addition to methods and compositions for its preparation and pharmacological analysis. The sequences disclosed herein may be used directly in the preparation of genetic ...
Testosterone is irreversibly metabolized to dihydrotestosterone, the most potent androgen (DHT), by steroid 5α-reductase type II enzyme (gene on 2p23, MIM 607306). Normal prostate growth and development requires DHT and functioning ofSRD5A2. In turn, DHT stimulates the transcription of several ge...
Disclosed are methods and compositions for the preparation of steroid 5&agr;-reductases by recombinant means, as well as for the use of these enzymes in screening assays for the identification of compounds which have the ability to inhibit or otherwise alter the enzymatic function of these enzymes...
enzyme activity, as evidenced by the increased apparentVmax(Fig.3), which strongly suggest a gain-of-function effect. This observation is supported by a previous study showing that some missense SRD5A2 mutations do not impair but increase the steroid 5α-reductase activity (Makridakis et al....
The concentrations of 5a-reductase are highest in certain peripheral tissues, including genital skin and hair follicles, and is localized intracellularly in apparent association with the nuclear membrane. DHT exerts its biological action by intracellular binding to the androgen receptor; this...
ADX or inhibition of 5a- reduced steroid synthesis with the 5a-reductase (5a-R) inhibitor finasteride reduces some of the behavioral effects of ethanol, including the anticonvulsant (VanDoren et al, 2000), antidepressant-like (Hirani et al, 2002), and anxio- lytic-like (Hirani et al, 2005)...