The enzyme 5伪-reductase (SRD5A) is involved in the conversion of testosterone to 5伪-dihydrotestosterone, both required for the development and maintenance of male reproductive function. Here, we evaluated, by western blotting analysis, the presence of SRD5A in human ejaculated spermatozoa and ...
Disclosed are methods and compositions for the preparation of steroid 5&agr;-reductases by recombinant means, as well as for the use of these enzymes in screening assays for the identification of compounds which have the ability to inhibit or otherwise alter the enzymatic function of these enzymes...
cellsDisclosed are methods and compositions for the preparation of steroid 5 alpha-reductases by recombinant means, as well as for the use of these enzymes in screening assays for the identification of compounds which have the ability to inhibit or otherwise alter the enzymatic function of these ...
摘要: We describe, here, the case report and detailed pelvic magnetic resonance imaging (MRI) aspect of a 17-year-old female XY teenager in which 5-α-reductase deficiency was caused by the homozygous Gly115Asp lost of function SRD5A2 mutation.关键词:...
1 External genitalia of three children (46,XY) with steroid 5a-reductase 2 deficiency 403 were carried out using specific primers and amplification conditions previously described (Vilchis et al. 1997; Cha´- vez et al. 2000). PCR fragments showing an aberrant mobility pattern on SSCP were ...
ADX or inhibition of 5a- reduced steroid synthesis with the 5a-reductase (5a-R) inhibitor finasteride reduces some of the behavioral effects of ethanol, including the anticonvulsant (VanDoren et al, 2000), antidepressant-like (Hirani et al, 2002), and anxio- lytic-like (Hirani et al, 2005)...
EIF5A hypusination dependency of mitochondrial protein translation suggested that decreased mitochondrial biogenesis and function may be responsible for polyamine mediated BRAFi resistance in melanoma. Indeed, treatment of A375VR and SK-mel-28VR cells with GC-7, DFMO or sardomozide decreased EIF5A hy...
Among these are genes encoding subunits of the cytochrome c oxidase (subunit VIc) and reductase (ubiquinone-binding protein) complexes. In addition, a ... MJ Evans,RC Scarpulla - 《Genes Dev》 被引量: 1650发表: 1990年 Assembly of Cytochrome c Oxidase within the Mitochondrion Cytochrome c oxi...
5α-reductase type 1 (5αRD1) is encoded bySRD5A1, which maps to the short arm of chromosome 5p15[18]and is expressed in the adult liver, non-genital skin and some brainareas. HumanSRD5A1,similar toSRD5A2,has five exons and four introns and encodes a 259 amino acid protein with a...
and the shape and function of the heart can be visually observed in living embryos. However, so far, there have been, despite this advantage, to the best of our knowledge, no reports of any existing studies onasb5function in zebrafish. By consulting the database, we found thatasb5is divi...