View and buy high purity Ro 60-0175 fumarate. Potent, selective 5-HT2C agonist. Cited in 10 publications.
In some embodiments, provided is a compound of Formula A as defined herein that modulates the activity of the 5-HT2C receptor. In some embodiments, for weight management, to induce satiety, and to reduce food intake, and obesity, antipsychotic-induced weight gain, type 2 diabetes, Prader-...
Centre for Addiction and Mental Health, Toronto, ON, Canada; 4Department Psychiatry & Psychology, University of Toronto, Toronto, ON, Canada Lorcaserin ((1R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine HCl) is a selective 5-HT2C receptor agonist with clinical efficacy in phase-...
5-HT2A receptor agonist-2用途 5-HT2A受体激动剂-2是一种高效的5-HT2受体激动剂。5-HT2A受体激动剂-2分别以1.7、0.58和0.50 nM的EC50值激发5-HT2A、5-HT2B和5-HT2C[1]。 5-HT2A receptor agonist-2名称 英文名5-HT2A receptor agonist-2 ...
Advancements in precision medicine drive the 5-HT2 agonist market by enabling selective targeting of specific receptor subtypes (e.g., 5-HT2A or 5-HT2C), reducing side effects and improving safety. Personalized approach...
Background: The serotonin 5-HT2Creceptor (5-HT2CR) is expressed in amygdala, a region involved in anxiety and fear responses and implicated in the pathogenesis of several psychiatric disorders such as acute anxiety and post traumatic stress disorder. In humans and in rodent models, there is ev...
5HT2c receptor agonist for the treatment of obesit 专利名称：5HT2c receptor agonist for the treatment of obesity and diabetes 发明人：ブレンチ，トビー・ジョナサン,ヘーベイゼン，パ ウル,リヒター，ハンス,ローバー，シュテファン 申请号：JP2006515997 申请日：20040618 公开号：JP2007506667...
www.nature.com/scientificreports OPEN Evaluation of a 5‑HT2B receptor agonist in a murine model of amyotrophic lateral sclerosis Alizée Arnoux1,2,3, Estelle Ayme‑Dietrich2, Stéphane Dieterle1, Marc‑Antoine Goy1, Stephan Schann3, Mélanie Frauli3, Laurent ...
Somewhat similar effects were observed with lorcaserin, a 5-HT2C agonist with potent 5-HT2B and 5-HT2A agonist activities, which is approved for treating obesity. Microdialysis studies revealed that both JJ-3-42 and lorcaserin reduced dopamine efflux in the infralimbic cortex, while only JJ-3-...
5HT2C receptor agonistPyrazinobenoxazinoneAnorecticObesitySubstituted 2,3,4,4a-tetrahydropyrazino[2,1-c][1,4]benzoxazin-5-(1H)-ones were synthesized and evaluated as 5-HT(2C) receptor agonists for the possible treatment of obesity. A number of compounds exhibited 5-HT(2C) agonist binding ...