Agomelatine, 99%, a competitive antagonist of (5-HT2C) receptors 市场价:¥214.00 商城价:¥182.00 100% 好评率 5 累计销量 满100包邮:消费满100元包邮商品品牌: J&K 商品规格: 1G 5G商品运费: 运费15元 商品数量: (库存5)立即购买 加入购物车 咨询 收藏 举报...
However, varying the route of administration for both compounds differentially revealed that an augmentation took place when the 5-HT2C antagonist was locally infused into ventral hippocampus and the SSRI given systemically, but not when systemic 5-HT2C antagonist was co-administered with the local in...
SB 206553 hydrochloride is an orally active, selective, and efficient 5-HT2C inverse agonist and 5-HT2C/5-HT2B receptor antagonist with anti-anxiety activity. It is useful in neurological disease research. 体外活性 SB 206553 hydrochloride (50 μM),阻止了 α-Me-5HT (10 μM) 应用诱发的 mEPSC...
[1]. Hu W, et al. Puerarin inhibits iNOS, COX-2 and CRP expression via suppression of NF-κB activation in LPS-induced RAW264.7 macrophage cells. Pharmacol Rep. 2011;63(3):781-9. [2]. Zhang H, et al. Puerarin: a novel antagonist to inward rectifier potassium channel (IK1). Mol ...
Indeed it has the double feature of being, on the one hand, an agonist of melatoninergic system receptors and, on the other hand, an antagonist of the 5-HT2C receptor. Those properties confer activity in the central nervous system and, more especially, in the treatment of severe depression,...
3-Hydroxy agomelatine (3-Hydroxyagomelatine) is a 5-HT2C receptor antagonist used in the study of neurological disorders. 靶点活性 5-HT2C receptor:1.8 μM (ki), 5-HT2C receptor:3.2 μM 体外活性 阿戈美拉汀 和 S 21517 对 5-HT2C 受体 具有相对较强的亲和力,Ki 值分别为 0.21 μM 和 0.13 μ...
Orthostatic intolerance induced by the 5-HT2C antagonist SB-247853 in healthy volunteers during head-up tiltingClinical Pharmacology & Therapeutics, the most cited journal publishing primary investigation in pharmacology and pharmacy, is the authoritative, cross-disciplinary journal in experimental and ...
SB 206553;SB 206553 HCL;SB 206553 HYDROCHLORIDE;SB-206553 hydrochloride hydrate;SB-206553 hydrate hydrochloride;1-amino-2-bromo-4-(2-methylanilino)anthracene-9,10-dione;SB 206553 hydrochloride, 5-HT2B and 5-HT2C receptor antagonist;5-METHYL-1-(3-PYRIDYLCARBAMOYL)-1,2,3,5-TETRAHYDROPYRROLO [...
(or inverse agonists) and agonists: keeping in mind that a number of antidepressants and antipsychotics are 5-HT2CR antagonists/inverse agonists. Agomelatine, a 5-HT2CR antagonist is registered for the treatment of major depression. The agonist Lorcaserin is registered for the treatment of aspect...
Antagonist of the 5-HT2C receptor; antidepressant; nervous system dosorders; excellent purity; storage stability; crystalline form obtained by high energy mechanical grinding or heating to melt compound and immediately cooling at room temperture; perfectly reproducible for easy dissolution or formulationUS...