SB 206553 hydrochloride is an orally active, selective, and efficient 5-HT2C inverse agonist and 5-HT2C/5-HT2B receptor antagonist with anti-anxiety activity. It is useful in neurological disease research. 体外活性 SB 206553 hydrochloride (50 μM),阻止了 α-Me-5HT (10 μM) 应用诱发的 mEPSC...
Modeling tardive dyskinesia: predictive 5-HT2C receptor antagonist treatment. Neurotox. Res. 11, 41-50.Kostrzewa, R.M.; Huang, N.Y.; Kostrzewa, J.P.; Nowak, P.; Brus, R. Modeling tardive dyskinesia: predictive 5-HT2C receptor antagonist treatment. Neurotox. Res., 2007, 11(1), 41-50...
Antagonist of the 5-HT2C receptor; antidepressant; nervous system dosorders; excellent purity; storage stability; crystalline form obtained by high energy mechanical grinding or heating to melt compound and immediately cooling at room temperture; perfectly reproducible for easy dissolution or formulationUS...
[1]. Hu W, et al. Puerarin inhibits iNOS, COX-2 and CRP expression via suppression of NF-κB activation in LPS-induced RAW264.7 macrophage cells. Pharmacol Rep. 2011;63(3):781-9. [2]. Zhang H, et al. Puerarin: a novel antagonist to inward rectifier potassium channel (IK1). Mol ...
SB 206553;SB 206553 HCL;SB 206553 HYDROCHLORIDE;SB-206553 hydrochloride hydrate;SB-206553 hydrate hydrochloride;1-amino-2-bromo-4-(2-methylanilino)anthracene-9,10-dione;SB 206553 hydrochloride, 5-HT2B and 5-HT2C receptor antagonist;5-METHYL-1-(3-PYRIDYLCARBAMOYL)-1,2,3,5-TETRAHYDROPYRROLO [...
Indeed it has the double feature of being, on the one hand, an agonist of melatoninergic system receptors and, on the other hand, an antagonist of the 5-HT2C receptor. Those properties confer activity in the central nervous system and, more especially, in the treatment of severe depression,...
3-Hydroxy agomelatine (3-Hydroxyagomelatine) is a 5-HT2C receptor antagonist used in the study of neurological disorders. 靶点活性 5-HT2C receptor:1.8 μM (ki), 5-HT2C receptor:3.2 μM 体外活性 阿戈美拉汀 和 S 21517 对 5-HT2C 受体 具有相对较强的亲和力,Ki 值分别为 0.21 μM 和 0.13 μ...
Orthostatic intolerance induced by the 5-HT2C antagonist SB-247853 in healthy volunteers during head-up tiltingClinical Pharmacology & Therapeutics, the most cited journal publishing primary investigation in pharmacology and pharmacy, is the authoritative, cross-disciplinary journal in experimental and ...
New York, Marcel Dekker Inc., pp 111–148 Di Matteo V, Di Giovanni G, Di Mascio M, Esposito E (1999): SB 242084, a selective serotonin2C receptor antagonist, increases dopaminergic transmission in the mesolimbic system. Neuropharmacology 38:1195–1205 Dugovic C, Wauquier A (1987): 5HT...
Indolderivate als 5-HT2C-Antagonisten, Verfahren zu deren Herstellung, sowie diese enthaltende pharmazeutische Zusammensetzungen 发明人: LAVIELLE, GILBERT;MULLER, OLIVIER;MILLAN, MARK;GOBERT, ALAIN 申请人: 申请日期: 2003-03-26 申请公布日期: 2006-06-22 代理机构: 代理人: 地址: 摘要: 二...