US5753663 1996年9月24日 1998年5月19日 Syntex (U.S.A.) Inc. Pyrimidine derivativesUS5753663 1996年9月24日 1998年5月19日 Syntex (U.S.A.) Inc. 5ht2c antagonist, useful for treating anxiety, pain, obsessive compulsive disorder, alcoholism, depression, migraine, sleep disorder, anorexia ...
One prominent finding was the anxiolytic ability of the 5-HT 2C R agonist and the anti-depressive ability of the 5-HT 2C R antagonist on the 7 th -day treatment. Though the exact mechanism of action is not clear, their ability to equilibrate brain redox status, restoring Ca 2+ level ...
Agomelatine, 99%, a competitive antagonist of (5-HT2C) receptors 市场价:¥214.00 商城价:¥182.00 100% 好评率 5 累计销量 满100包邮:消费满100元包邮商品品牌: J&K 商品规格: 1G 5G商品运费: 运费15元 商品数量: (库存5)立即购买 加入购物车 咨询 收藏 举报...
Antagonist of the 5-HT2C receptor; antidepressant; nervous system dosorders; excellent purity; storage stability; crystalline form obtained by high energy mechanical grinding or heating to melt compound and immediately cooling at room temperture; perfectly reproducible for easy dissolution or formulationUS...
Compounds of formula (I) or a salt thereof, wherein R4 is a group of formula (i), a group of formula (ii) or a group of formula (iii) have been found to have 5HT2C receptor antagonist activity. Some or all of the compounds of the invention also exhibit 5HT2B antagonist activity. ...
5-HT2A receptor Antagonist (86)5-HT2B receptor Antagonist (50)5-HT2C receptor Antagonist (54)所有研究领域 Skip to the end of the images gallery Skip to the beginning of the images gallery 基本描述 别名N-[3-氟-5-(3-吡啶基)苯基] -2,3-二氢-5-甲氧基-6-(三氟甲基)-1H-吲哚-1-羧酰...
Orthostatic intolerance induced by the 5-HT2C antagonist SB-247853 in healthy volunteers during head-up tiltingClinical Pharmacology & Therapeutics, the most cited journal publishing primary investigation in pharmacology and pharmacy, is the authoritative, cross-disciplinary journal in experimental and ...
[2]. Zhang H, et al. Puerarin: a novel antagonist to inward rectifier potassium channel (IK1). Mol Cell Biochem. 2011 Jun;352(1-2):117-23. [3]. Zhao L,et al. Protective Effects of Genistein and Puerarin against Chronic Alcohol-Induced Liver Injury in Mice via Antioxidant, Anti-infla...
The primary pharma- cological property of lorcaserin is 5-HT2C receptor activation (Thomsen et al, 2008; Fletcher et al, 2009a, b), and the demonstration that its effects on food- and nicotine-related behaviors were blocked by the selective 5- HT2C antagonist SB-242084 (Kennett et al, ...
Agomelatine, a 5-HT2CR antagonist is registered for the treatment of major depression. The agonist Lorcaserin is registered for the treatment of aspects of obesity and has further potential in addiction, especially nicotine/ smoking. There is good evidence that the 5-HT2CR is involved in spina...