The present study examined the effects of the 5-HT2Creceptor agonist meta-chlorophenylpiperazine (mCPP) on food consumption, eating microstructure and blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRI) responses to food pictures in healthy female volunteers. In a double-...
5HT2C receptor agonistPyrazinobenoxazinoneAnorecticObesitySubstituted 2,3,4,4a-tetrahydropyrazino[2,1-c][1,4]benzoxazin-5-(1H)-ones were synthesized and evaluated as 5-HT(2C) receptor agonists for the possible treatment of obesity. A number of compounds exhibited 5-HT(2C) agonist binding ...
One prominent finding was the anxiolytic ability of the 5-HT 2C R agonist and the anti-depressive ability of the 5-HT 2C R antagonist on the 7 th -day treatment. Though the exact mechanism of action is not clear, their ability to equilibrate brain redox status, restoring Ca 2+ level ...
Centre for Addiction and Mental Health, Toronto, ON, Canada; 4Department Psychiatry & Psychology, University of Toronto, Toronto, ON, Canada Lorcaserin ((1R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine HCl) is a selective 5-HT2C receptor agonist with clinical efficacy in phase-...
Zhang B, Zhao S, Yang D, Wu Y, Xin Y, Cao H, Huang XP, Cai X, Sun W, Ye N, Xu Y, Peng Y, Zhao S, Liu ZJ, Zhong G, Wang MW, Shui W. A Novel G Protein-Biased and Subtype-Selective Agonist for a G Protein-Coupled Receptor Discovered from Screening Herbal Extracts. ACS ...
In low doses of 0.1 and 0.2 mg/kg, the agonist reduced anxiety, but had no effect on motor activity. It is hypothesized that low doses of MK-212 exhibited anxiolytic activity in mice.doi:10.1007/s10517-006-0427-2E. G. Kuznetsova...
(vehicle administration) between SERT +/+ and SERT -/- mice. However, the anxiogenic response induced by the 5-HT2R agonist mCPP in SERT +/+ mice was absent in SERT -/- mice. The role of 5-HT2CR in this anxiogenic response was confirmed by pretreatment with the selective 5-HT2CR...
化合物 5-HT2C AGONIST-3 CAS号: 2104810-18-4 英文名: 5-HT2C agonist-3 英文别名: 5-HT2C agonist-3 中文名: 化合物 5-HT2C AGONIST-3 中文别名: 化合物 5-HT2C AGONIST-3 CBNumber: CB914245180 分子式: 分子量: 0 MOL File: Mol file ...
More direct clinical evidence derives from the use of the prototypical 5-HT2C receptor agonist m-chlorophenylpiperazine (mCPP), with which both acute hypophagia and body-weight loss have been observed. The current paper therefore reviews both the pre-clinical and clinical evidence supporting the ...
Effect of the activation of central 5-HT2C receptors by the 5-HT2C agonist mCPP on blood pressure and heart rate in rats In the present study we investigated the role of central 5-HT 2C receptors in the control of blood pressure and heart rate in non-stressed and stressed, ad... HS ...