[22] Miwa H, Nagahara A, Tominaga K, et al. Efficacy of the 5-HT1A agonist tandospirone citrate in improving symptoms of patients with functional dyspepsia: a randomized controlled trial[J]. Am J Gastroenterol, 2009,104(...
[16] Sato S, Mizukami K, Asada T. A preliminary open-label studyof 5-HT1A partial agonist tandospirone for behavioural and psychological symptoms associated with dementia[J]. Int JNeuropsychopharmacol, 2007,10(2):281-2...
In 1980, buspirone was found to have anxiolytic potential. This finding initiated the development of the azapirones — highly serotonin 5-HT1A agonist
Catalog No.: A11208 5-HT1A agonist BMY 7378 is a 5-HT1A partial agonist and high affinity α1D adrenoceptor antagonist. Skip to the end of the images gallery Skip to the beginning of the images gallery Grouped product items SizePriceStockQty ...
A 5-HT1A receptor full agonist with 5-HT2A receptor antagonistic activity; It was initially investigated as an potential antidepressant, however, it is currently under clinical trial for the potential treatment of female sexual dysfunction. References: E Jolly et al. Design of Phase III pivotal...
Rats received daily injections of either 50 or 25 ng of the 5-HT1A receptor agonist 8-OH-DPAT or a vehicle solution into the BLA and mutual-reward choices were measured in a rodent prosocial choice task. Compared to vehicle injections, 8-OH-DPAT significantly increased mutual-reward choices ...
In vivo, F 11440 was 4- to 20-fold more potent than flesinoxan, and 30- to 60-fold more potent than buspirone, in exerting 5-HT1A agonist activity at pre- and postsynaptic receptors in rats (measured by, for example, its ability to decrease hippocampal extracellular serotonin (5-HT) ...
Effect of adjunctive treatment with serotonin-1A agonist tandospirone on memory functions in schizophrenia[J]. J Clin Psychopharmacol, 2000,20(3):386-388. [11] Sumiyoshi T, Higuchi Y, Matsui M, et al. Effective adjunctive use of tandospirone with perospirone for enhancing verbal memory and ...
We have recently demonstrated, in rats and rabbits, that microinjection of selective serotonin-1A (5-HT1A) receptor agonist 8-OH-DPAT into this area dramatically reduces tachycardia elicited by psychological stresses. This effect was mimicked by systemic administration of the agonist. We further ...
Description: Befiradol (free base) is a highly selective and potent 5-HT1A receptor agonist potentially for the treatment of drug-induced dyskinesia in patients with Parkinson's disease. Chemical Structure Befiradol (free base) CAS# 208110-64-9 Instruction Theoretical Analysis MedKoo Cat#: ...