receptor antagonist activity profile. 5HT2C receptor antagonists are believed to be of potential use in the treatment of CNS disorders such as anxiety, depression, epilepsy, obsessive compulsive disorders, migraine, Alzheimer's disease, sleep disorders, feeding disorders such as anorexia and bulimia, ...
SB 206553;SB 206553 HCL;SB 206553 HYDROCHLORIDE;SB-206553 hydrochloride hydrate;SB-206553 hydrate hydrochloride;1-amino-2-bromo-4-(2-methylanilino)anthracene-9,10-dione;SB 206553 hydrochloride, 5-HT2B and 5-HT2C receptor antagonist;5-METHYL-1-(3-PYRIDYLCARBAMOYL)-1,2,3,5-TETRAHYDROPYRROLO [...
3-Hydroxy agomelatine (3-Hydroxyagomelatine) is a 5-HT2C receptor antagonist used in the study of neurological disorders. 靶点活性 5-HT2C receptor:1.8 μM (ki), 5-HT2C receptor:3.2 μM 体外活性 阿戈美拉汀 和 S 21517 对 5-HT2C 受体 具有相对较强的亲和力,Ki 值分别为 0.21 μM 和 0.13 μ...
SB 206553 hydrochloride is an orally active, selective, and efficient 5-HT2C inverse agonist and 5-HT2C/5-HT2B receptor antagonist with anti-anxiety activity. It is useful in neurological disease research. 体外活性 SB 206553 hydrochloride (50 μM),阻止了 α-Me-5HT (10 μM) 应用诱发的 mEPSC...
Ketanserin 是一种特异性的5-HT2A 5-羟色胺受体拮抗剂,作用于大鼠和人5-HT2A,Ki为2.5 nM。 靶点(IC50 & Targe) 5-HT2A,2.5nM(Ki) 5-HT2C (Human),100nM(Ki) 5-HT2C (Rat),50nM(Ki) 体外研究 在分离的大鼠尾动脉,犬基底,颈动脉,冠状动脉和胃脾动脉,犬胃脾静脉和犬隐静脉中,Ketanserin剂量依赖性...
5-HT Receptor (262)5-HT2B receptor Antagonist (47)5-HT2C receptor Antagonist (51)GPCR/G Protein (3177)神经元信号传导 (3338) Skip to the end of the images gallery Skip to the beginning of the images gallery 基本描述 别名N-(1-甲基-1H-吲哚-5-基)-N'-(3-甲基-5-异噻唑基)脲 ...
Interestingly, the phenotype of 2CKO mice in the 5-CSRTT was not mimicked by treatment with the 5-HT2C receptor antagonist SB242084, which enhanced premature responses in WT, but not in 2CKO mice. This discrepancy between the impact of constitutive loss of 5-HT2C receptors and that of ...
MDL 11,939 is an orally active 5-HT2A receptor antagonist; displays selectivity for 5-HT2A receptors over 5-HT2C receptors (Ki values are 0.54, 2.5, 81.6 and ~10,000 nM at rabbit 5-HT2A, human 5-HT2A, rabbit 5-HT2C and human 5-HT2C receptors respectively).技术...
Indeed it has the double feature of being, on the one hand, an agonist of melatoninergic system receptors and, on the other hand, an antagonist of the 5-HT2C receptor. Those properties confer activity in the central nervous system and, more especially, in the treatment of severe depression,...
SB-200646 is a selective and potent antagonist of 5-HT2B/5-HT2C receptor 靶点活性 5-HT2B receptor:7.5 (pKi) , 5-HT2A receptor:5.2 (pKi), 5-HT2C receptor:6.9 (pKi) 化学信息 分子量 266.3 分子式 C15H14N4O CAS No. 143797-63-1 Smiles CN1C=2C(=CC(NC(NC=3C=CC=NC3)=O)=CC2...