5-HT2A receptor5-HT2C receptor57-DHTRationale Global serotonin (5-HT) depletion increases the number of premature responses made on the five-choice serial reaction time task (5CSRT) in rats. In contrast, the 5-HT2Areceptor antagonist......
Indeed it has the double feature of being, on the one hand, an agonist of melatoninergic system receptors and, on the other hand, an antagonist of the 5-HT2C receptor. Those properties confer activity in the central nervous system and, more especially, in the treatment of severe depression,...
Using this animal model, we have attempted to understand the serotonergic system in the hippocampus and prefrontal cortex, while using the 5-HT 2C R agonist and antagonist in evaluating 5-HT 2C receptor neurotransmission. A decrease in serotonin (5-HT) level, tryptophan hydroxylase-2 activity ...
5-HT2A receptor Antagonist (86)5-HT2B receptor Antagonist (50)5-HT2C receptor Antagonist (54)所有研究领域 Skip to the end of the images gallery Skip to the beginning of the images gallery 基本描述 别名N-[3-氟-5-(3-吡啶基)苯基] -2,3-二氢-5-甲氧基-6-(三氟甲基)-1H-吲哚-1-羧酰...
Antagonist of the 5-HT2C receptor; antidepressant; nervous system dosorders; excellent purity; storage stability; crystalline form obtained by high energy mechanical grinding or heating to melt compound and immediately cooling at room temperture; perfectly reproducible for easy dissolution or formulationUS...
5-HT Receptor5-HT2B receptor Antagonist5-HT2C receptor AntagonistGPCR/G ProteinNeuronal Signaling Skip to the end of the images gallery Skip to the beginning of the images gallery 基本描述 别名N-(1-甲基-1H-吲哚-5-基)-N'-(3-甲基-5-异噻唑基)脲 ...
5-HT2C receptor agonists: pharmacological characteristics and therapeutic potential. J Pharmacol Exp Ther 286: 913–924. CAS PubMed Google Scholar Maura G, Marcoli M, Tortarolo M, Andrioli GC, Raiteri M (1998). Glutamate release in human cerebral cortex and its modulation by 5-...
Several 5-HT2C agonists are in development or on the market to treat not only food intake and obesity, but also various types of addiction, including smoking and possibly drug-related addictions. In addition, the antidepressant agomelatine is melatonin receptor agonist and 5-HT2C receptor antagonist...
Interestingly, the phenotype of 2CKO mice in the 5-CSRTT was not mimicked by treatment with the 5-HT2C receptor antagonist SB242084, which enhanced premature responses in WT, but not in 2CKO mice. This discrepancy between the impact of constitutive loss of 5-HT2C receptors and that of ...
Fletcher PJ, Grottick AJ, Higgins GA (2002a) Differential effects of the 5-HT2A receptor antagonist M100,907 and the 5-HT2C receptor antagonist SB242,084 on cocaine-induced locomotor activity, cocaine self-administration and cocaine-induced reinstatement of responding. Neuropsychopharmacology 27:576...