这些数据充分说明5-HT1A受体拮抗剂通过激活CREB/BDNF通路,增强PSD-95、GAP-43、Syn表达,促进突触重塑,保护大鼠海马神经元细胞,从而改善七氟烷致老年认知功能障碍模型大鼠的学习记忆能力。参考文献:ZOU Jiarui, CHEN Keyan, ZHANG Zhen. Effects of the 5-HT1A receptor antagonist on synaptic plasticity in ...
近年来通过改善海马突触可塑性提高认知功能的策略得到广泛认同,其中环磷酸腺苷反应原件结合蛋白(cAMPresponse element binding protein,CREB)/脑源性神经营养因子(brain-derived neurotrophic factor,BDNF)信号通路尤为重要。 5-羟色胺(5-hydroxytryptamine,5-HT)主要分布于海马体,是一种常见的神经递质,参与认知功能与情绪...
近年来通过改善海马突触可塑性提高认知功能的策略得到广泛认同,其中环磷酸腺苷反应原件结合蛋白(cAMPresponse element binding protein,CREB)/脑源性神经营养因子(brain-derived neurotrophic factor,BDNF)信号通路尤为重要。 5-羟色胺(5-hydroxytryptamine,5-HT)主要分布于海马体,是一种常见的神经递质,参与认知功能与情绪...
5-羟色胺(5-hydroxytryptamine,5-HT)主要分布于海马体,是一种常见的神经递质,参与认知功能与情绪调节等生物活动。5-HT1A受体在海马组织表达最多。 来自大连理工大学附属中心医院麻醉科及中国医科大学实验动物部的研究人员应用七氟烷构建老年认知功能障碍大鼠模型,将30只18月龄Sprague-Dawley大鼠随机分为对照组、模型组...
Popova NK, Ivanova EA (2002) 5-HT(1A) receptor antagonist p-MPPI at- tenuates acute ethanol effects in mice and rats. Neurosci Lett 322:1- 4.Popova N.K., Ivanova E.A. 2002. 5-HT 1A receptor antagonist p-MPPI attenuates acute ethanol effects in mice and rats. Neurosci. Lett. 322...
Understanding the relationship and interaction of 5-HT and calcium channels are essential for determining how pentobarbital causes anesthesia. Accordingly, -2- we have investigated the role of 5-HT1A receptor agonist 8-OH-DPAT and antagonist p-MPPI in the augmentative effects of diltiazem on ...
用于治疗偏头痛的药物麦角胺,二氢麦角胺 是由 5-HT1B/1D 受体和 α2-肾上腺素受体介导血管 收缩效应[5],而舒马曲坦则完全由 5-HT1B 受体介 导.(2)抑制降钙素基因相关肽(CGRP),P 物质, 神经肽等释放.研究表明,5-HT 通过 5-HT1 受体 抑制 CGRP,谷氨酸释放[6],信号传递是通过激活 Gαi/Gαo 类...
In the present experiment, a selective, silent 5-HT1A receptor antagonist, (+)-WAY 100135 (N-tert-butyl 3-4(2-methoxyphenyl) piperazin 1-yl-2-phenyllpropanamide dihydrochloride), was used to further study the role of 5-HT activation in dizocilpine-induced behaviours. At a dose of 10 mg...
(di-n-propylamino)tetralin (8-OH-DPAT), a 5-HT 1A receptor agonist, and 5 and 10 mg/kg ipsapirone, a partial agonist at these receptors, increased the rates of punished responding, whereas (S)-WAY 100135, a 5-HT 1A receptor antagonist, had no effect at doses from 1 to 10 mg/...
1Recent evidence suggests that the novel compound SDZ 216525 is a selective and possibly silent 5-HT1A receptor antagonist. Here we have examined the action of SDZ 216525 on central 5-HT1A autoreceptor function. The experiments involved measurement of drug effects on extracellular 5-HT in the ...