5-HT1BD receptor antagonist5-HT neurotransmission1. 1. 5-Hydroxytryptamine-1B (5-HT1B, formerly designated 5-HT1Dβ) and 5-hydroxy-tryptamine-1D (5-HT1D, formerly designated 5-HT1Dα) receptors are distinct molecular entities that mediate serotonergic neurotransmission. Both are G-protein-...
这些数据充分说明5-HT1A受体拮抗剂通过激活CREB/BDNF通路，增强PSD-95、GAP-43、Syn表达，促进突触重塑，保护大鼠海马神经元细胞，从而改善七氟烷致老年认知功能障碍模型大鼠的学习记忆能力。参考文献：ZOU Jiarui, CHEN Keyan, ZHANG Zhen. Effects of the 5-HT1A receptor antagonist on synaptic plasticity in ...
近年来通过改善海马突触可塑性提高认知功能的策略得到广泛认同,其中环磷酸腺苷反应原件结合蛋白(cAMPresponse element binding protein,CREB)/脑源性神经营养因子(brain-derived neurotrophic factor,BDNF)信号通路尤为重要。 5-羟色胺(5-hydroxytryptamine,5-HT)主要分布于海马体,是一种常见的神经递质,参与认知功能与情绪...
1Recent evidence suggests that the novel compound SDZ 216525 is a selective and possibly silent 5-HT1A receptor antagonist. Here we have examined the action of SDZ 216525 on central 5-HT1A autoreceptor function. The experiments involved measurement of drug effects on extracellular 5-HT in the ...
5-羟色胺(5-hydroxytryptamine,5-HT)主要分布于海马体,是一种常见的神经递质,参与认知功能与情绪调节等生物活动。5-HT1A受体在海马组织表达最多。 来自大连理工大学附属中心医院麻醉科及中国医科大学实验动物部的研究人员应用七氟烷构建老年认知功能障碍大鼠模型,将30只18月龄Sprague-Dawley大鼠随机分为对照组、模型组...
参考文献:ZOU Jiarui, CHEN Keyan, ZHANG Zhen. Effects of the 5-HT1A receptor antagonist on synaptic plasticity in sevoflurane-induced cognitive dysfunction in aged rats and its mechanism[J]. Journal of China Medical University, 2024, 53(1): 60-66,74....
In the present experiment, a selective, silent 5-HT1A receptor antagonist, (+)-WAY 100135 (N-tert-butyl 3-4(2-methoxyphenyl) piperazin 1-yl-2-phenyllpropanamide dihydrochloride), was used to further study the role of 5-HT activation in dizocilpine-induced behaviours. At a dose of 10 mg...
Several partial agonists display only antagonist activity in models of postsynaptic 5-HT 1A receptor function, whereas their agonist properties are revealed in models of presynaptic, somatodendritic 5-HT 1A autoreceptor function. In view of these considerations, the term 'silent antagonist' has been ...
5-羟色胺(5-hydroxytryptamine,5-HT)主要分布于海马体,是一种常见的神经递质,参与认知功能与情绪调节等生物活动。5-HT1A受体在海马组织表达最多。 来自大连理工大学附属中心医院麻醉科及中国医科大学实验动物部的研究人员应用七氟烷构建老年认知功能障碍大鼠模型,将30只18月龄Sprague-Dawley大鼠随机分为对照组、模型组...
血清素(英语:Serotonin,全称血清张力素,又称5-羟色胺和血清胺,简称为5-HT)为单胺型神经递质,由色氨酸经色氨酸羟化酶转化为5-羟色氨酸,再经5-羟色氨酸脱羧酶在中枢神经元及动物(包含人类)消化道之肠嗜铬细胞中合成。5-羟色胺主要存在于动物(包括人类)的胃肠道、血小板和中枢神经系统中。它被普遍认为是幸福...