这些数据充分说明5-HT1A受体拮抗剂通过激活CREB/BDNF通路，增强PSD-95、GAP-43、Syn表达，促进突触重塑，保护大鼠海马神经元细胞，从而改善七氟烷致老年认知功能障碍模型大鼠的学习记忆能力。参考文献：ZOU Jiarui, CHEN Keyan, ZHANG Zhen. Effects of the 5-HT1A receptor antagonist on synaptic plasticity in ...
1Recent evidence suggests that the novel compound SDZ 216525 is a selective and possibly silent 5-HT1A receptor antagonist. Here we have examined the action of SDZ 216525 on central 5-HT1A autoreceptor function. The experiments involved measurement of drug effects on extracellular 5-HT in the ...
Although, human 5-HT(1B) and 5-HT(1D) receptors have been pharmacologically differentiated using nonselective 5-HT(1B/D) receptor antagonists such as ketanserin (1), ritanserin (2) and methiothepin (3), the precise function of these receptors remains undefined, and progress toward this ha...
1,遗传因素:重性抑郁症的遗传概率可能在31%~ 42%,而复发性重性抑郁症,遗传水平可能更高; 2,神经递质系统:单胺类假说是在20世纪被提出的,多数临床实验显示单胺类神经递质如5-HT和DA浓度的降低是诱导抑郁症发生的主要原因之一; 3,神经营养因子假说:该假说认为,神经营养因子特别是脑源性神经营养因子( BDNF) 的...
用于治疗偏头痛的药物麦角胺,二氢麦角胺 是由 5-HT1B/1D 受体和 α2-肾上腺素受体介导血管 收缩效应[5],而舒马曲坦则完全由 5-HT1B 受体介 导.(2)抑制降钙素基因相关肽(CGRP),P 物质, 神经肽等释放.研究表明,5-HT 通过 5-HT1 受体 抑制 CGRP,谷氨酸释放[6],信号传递是通过激活 Gαi/Gαo 类...
SB 699551 is a selective 5-htreceptor antagonist (pKvalues are 8.3, < 6.0, < 6.0, < 6.0, < 5.5 and < 5.5 for 5-ht, 5-HT, 5-HT2A, 5-HT2C, 5-HT1Aand 5-HT7receptors respectively). Technical Data M.Wt: 584.66 Formula:
Key words:ITI-007serotonin receptor antagonistschizophrenianegative symptoms 1 药物概况 别名:ITI-007 化学名:4-((6bR,10aS)-3-甲基-2,3,6b,9,10,10a- 六氢-1H,7H-吡啶[3',4':4,5]吡咯[1,2,3-de]喹啉- 8-基-1-4-氟苯基-1-丁酮 ...
Risperidone (R-64766) is a mutil-targeted antagonist for dopamine, serotonin, adrenergic and histamine receptors, used to treat schizophrenia and bipolar disorder.
5-HT2 antagonist 1 是一种有效的 5-HT2 receptor 拮抗剂,同时对 α1 adrenoceptor 有微弱地抑制作用。
However, after long-term treatment with the tricyclic antidepressant imipramine, the selective 5-HT reuptake inhibitor paroxetine, the reversible monoamine oxidase-A inhibitor befloxatone, the alpha2-adrenergic antagonist mirtazapine, or the 5-HT1A receptor agonist gepirone or multiple electroconvulsive ...