尽管大量的动物实验表明5-HT2CR的功能缺失会导致肥胖发生，但是尚未有研究发现5-HT2CR的功能缺失会导致人类肥胖发生的直接证据。2022年12月19日，贝勒医学院徐勇课题组与剑桥大学Sadaf Farooqi课题组合作在Nature Medicine上发表题为 Human loss-of-function variants in the Serotonin 2C receptor associated with obe...
近日,贝勒医学院徐勇团队于Science Advances发表文章“Neural circuits expressing the serotonin 2C receptor regulate memory in mice and humans”,揭示了5-HT影响记忆的心得神经机制,并发现一种5HT2C受体激动剂,减肥药氯卡色林,可能有助于减轻阿尔茨海默症导致的认知损伤。 图1 HTR2C突变导致小鼠记忆和海马可塑性的...
近日,贝勒医学院徐勇团队于Science Advances发表文章“Neural circuits expressing the serotonin 2C receptor regulate memory in mice and humans”,揭示了5-HT影响记忆的心得神经机制,并发现一种5HT2C受体激动剂,减肥药氯卡色林,可能有助于减轻阿尔茨海默症导致的认知损伤。 图1 HTR2C突变导致小鼠记忆和海马可塑性的...
5~HT2A 受体拮抗剂可以增强 5~羟色胺再摄取抑制剂等抗抑郁药对难治性抑郁症的治疗效果 并减少性功能障碍及睡眠障碍等不良反应ꎮ 目前有不少以 5~HT2A 受体为靶点的抗抑郁药应用于临床ꎬ也有大量化合物 处于临床及临床前研究ꎮ 该文对 5~HT2 A 受体与抑郁症的关系及以 5~HT2A 受体为靶点的抗抑郁药...
2022年12月19日,贝勒医学院徐勇课题组与剑桥大学Sadaf Farooqi课题组合作在Nature Medicine上发表题为Human loss-of-function variants in the Serotonin 2C receptor associated with obesity and maladaptive behavior的研究论文,首次发现5-HT2C...
在之前的一项工作中,贝勒医学院徐勇教授团队发现了一种罕见的5-HT2C受体(由基因HTR-2C基因编码)的loss-of-function突变会导致肥胖[1],且临床上这些患者出现了不同程度的认知障碍。那5-HT及其受体是如何影响认知与记忆的呢?近日,贝勒医学院徐勇团队于Science Advances发表文章“Neural circuits expressing the serotonin...
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5-HT2A, a G-protein coupled receptor, is widely expressed in the human body, including in the gastrointestinal tract, platelets and the nervous system. It mediates various functions, for e.g. learning, memory, mood regulation, platelet aggregation and va
attributed to the 5-HT2Asubtype. Because the two receptors were clearly members of the 5-HT2subfamily the 5-HT1Creceptor was renamed 5-HT2C(Barnes and Sharp, 1999). The gene encoding the 5-HT2Creceptor is X-linked in both humans and mice(Milatovich et al., 1992)....
The 5-HT 2C receptor was one of the first receptors of the 5-HT family to be cloned; although full-length sequences were difficult to obtain, due to a complex exon-intron structure. The receptor was mapped to human chromosome Xq24. Given its similar pharmacological and transductional ...