5-HT receptors
体外研究表明,ERVWE1通过ALKBH5的去甲基化作用降低HTR1B mRNA上的m6A修饰水平,增强HTR1B mRNA的稳定性,从而上调HTR1B的表达,激活下游通路,最终导致5-HT神经元可塑性的损伤。这些研究结果揭示了一个新的精神分裂症风险基因,并展示了ERVWE1通过表观遗传修饰调节5-HT神经元可塑性的新机制,为ERVWE1通过RNA修饰途径在...
Besides 5-HT effect through its receptors on the cell membrane13,14, the mechanism which we unveiled highlighted another novel path: 5-HT can directly acti- vate its functional receptors on the mitochondrial membrane, and regulate mitochondrial and cellular activities and functions. We first ...
The aim of the present study was to investigate the modulatory role of activated 5-HT, receptors in the central amygdala (CeA) on mitogen concanavalin A (ConA)-stimulated proliferative response of thymocytes in rats and the underlying neuroendocrine regulation circuits. 1-phenylbiguanide (PBG), a...
receptors15. Our results suggest that though there are differences in signaling between the rat and human receptors, these differences did not extend to cell–matrix adhesion, which was similar between the human and rat 5-HT2Aexpressed in HEK293 cells. Our current study adds to the functional ...
Demonstration of 5-HT3 receptor function and expression in the mouse bladder The aim of this study was to demonstrate the presence of 5-HT3 receptors in the mouse bladder and to determine their location. Bladder strips from female m... N Chetty,IM Coupar,CWP Kerr - Naunyn-Schmiedeberg's ...
The purpose of this study was to further examine the effect of activation of 5-HT(1A) and 5-HT(1B) receptors in the forced swim test in mice and to determine if activation of these receptors played a role in the mediation of the effects of the tricyclic antidepressant imipramine. The 5...
摘要: Focuses on serotonin (5-HT) 5-HT... receptors and neurotransmitter release in the central nervous system. Structure and function of the receptors; Release of 5-HT; Dopamine release; Cholecystokinin and GABA release; Acetylcholine and nonadrenaline release....
Role of 5-HT1B, 5-HT2A and 5-HT2C receptors in learning We studied the effects of the 5-HT 2 receptor antagonists, ritanserin and ketanserin, on the sleep of healthy volunteers in order to clarify the role of 5... A Meneses,E Hong 被引量: 0发表: 1997年 Role of 5-HT2A receptor...
Systemic administration of phenethylamine-derived, 5-hydroxytryptamine 2 (5-HT 2 ) receptor agonists inhibits the firing of midbrain 5-HT neurones, but the 5-HT receptors involved are poorly defined, and the contribution of peripheral mechanisms is uncertain. This study addresses these issues using...