2C T cell receptor (TCR) transgenic mice have been long used to study the molecular basis of TCR binding to peptide/major compatibility complexes and the cytotoxicity mechanism of cytotoxic T lymphocytes (CTLs). To study the role of variable gene promoters in allelic exclusion, we previously ...
First wave fetal thymocytes expressing V3J gamma 1C gamma 1-V delta 1J delta 2C delta T cell receptors are not required for alpha beta T cell receptor rear... We have determined the fetal expression of V gamma 3, delta and beta TcRs in transgenic for the V gamma 1.1J4C gamma 4 ...
Strength of T cell receptor (TCR) signaling, coreceptors, costimulation, antigen-presenting cell type, and cytokines all play crucial roles in determining the efficiency with which type 2 T lymphocytes (Th2, Tc2) develop from uncommitted precursors. To investigate in vivo regulatory mechanisms that...
Rearrangement and expression of T cell receptor and immunoglobulin loci in immortalized CD4−CDS−T cell lines Injection of newborn mice with mixtures of wild-type moloney murine leukemia (Mo-MuLV) virus and other recombinant retroviruses harboring the myc oncogene alone or in combination with the...
The mutant mice fail to... MM Santos - 《Journal of Experimental Medicine》 被引量: 0发表: 1996年 Transgenic αβ TCR tonic signaling is leukemogenic while strong stimulation is leukemia-suppressive The pre-T cell receptor (TCR) and TCR complexes are frequently expressed in T-cell acute ...
(clone M1/70), anti-T-cell receptor β (clone H57-597), anti-Gr-1 (clone RB6-8C5), anti-TCRγδ (clone GL3) and anti-CD45 (clone 30-F11) and conjugated with PE as described.24,29,31,32All monoclonal antibodies were added at saturating concentrations, and the cells were then ...
The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway. Mol. Cell 1998, 2, 887–893. [CrossRef] 23. Blondeau, F.; Laporte, J.; Bodin, S.; Superti-Furga, G.; Payrastre, B.; Mandel, J.L. Myotubularin, a phosphatase deficient in myo...
Therefore, our study provides important evidence on and elucidates the molecular mechanism associated with the role LFA-1 signaling plays in effector and memory CD8 T cell survival. 展开 关键词: TCR T cell receptor MHC major histocompatibility complex APC antigen-presenting cell AICD activation-...
T-cell and myeloid cell development and functions are intact, but reduced mature B-cell numbers due to their impaired survival, combined with germinal center defects, result in reduced humoral immune responses.24,25 Interestingly, with age, nfkb2− / − mice exhibit multiorgan leukocyte infilt...
Biochemical methods were applied to search for a binding partner of PrPC which is attached to the cell surface by a glycosylphosphatidylinositol GPI anchor (1). ... HA Kretzschmar,T Tings,A Madlung,... - 《Methods in Molecular Medicine》 被引量: 73发表: 2001年 Function of PrP as a ...