T-cell receptor transgenic mice in the study of autoimmune diseases. Journal of Autoimmunity 22: 95-106.Lafaille JJ (2004) T-cell receptor transgenic mice in the study of autoimmune diseases. J Autoimmunol 22:95–106Lafaille, J. J. 2004. T-cell receptor transgenic mice in the study of ...
Damage control, rather than unresponsiveness, effected by protective DX5+ T cells in autoimmune diabetes The progression of is regulated. We examined here the cellular controls exerted on disease that developed in the BDC2.5 T cell receptor-. We found that all... A Gonzalez,I Andre-Schmutz,C ...
TCR-beta (T cell receptor-beta chain) transgenic mice have altered lymphocyte development. TCR-beta transgenic mice are hyporesponsive to alloantigens in vivo and are deficient in gamma delta T cells. In order to begin a study of the relationship between a deficiency of alloreactive gamma delta...
The mechanisms that induce T cell tolerance to circulating self-proteins are still controversial, and both the deletion and selection of autoreactive T cells have been observed in the thymus of transgenic mouse models. To address the question of the induction of tolerance to circulating self-constit...
The striking and unique structural feature of the T cell receptor (TCR) β chain is the bulky solvent-exposed FG loop on the Cβ domain, the size of almost half an immunoglobulin domain. The location and size of this loop suggested immediately that it could be a crucial structural link bet...
Mus musculus B57BL/6 (HLA-A2.1 transgenic) T-cell receptor beta chain Vbeta 5.1 Jbeta 2.6 mRNA, partial cds Mus musculus B57BL/6 (HLA-A2.1 transgenic) T-cell receptor beta chain Vbeta 5.1 Jbeta 2.6 mRNA, partial cds1) To engineer a highly immunodominant ... S Man 被引量: 0发表...
A large number of V β 8 gene-encoded cDNA were analyzed from peripheral CD4 + and CD8 + T cell subsets of T cell receptor (TcR) α chain-transgenic mice. This analysis demonstrates that a limited repertoire of TcR β chains are co-expressed with the transgenic α chain. Most importantly...
D011.10 T-cell receptor Increased effects of T-cell activation on gastric permeability and reduces effects on small intestine permeability in response to ethanol Alnadjim et al. (2002) HIV-1 tat protein No change in neutrophil function upon ethanol administration Less proliferation of bone marrow ...
Here we show that a transgenic T cell receptor expression predisposes mice to leukemia/lymphoma development. Leukemia/lymphoma precursors expressed low amounts of MHC class I and were deleted by NK cells in immunocompetent mice resulting in increased tumor frequency under NK cell absence. Leukemias/...
A large number of Vβ8 gene‐encoded cDNA were analyzed from peripheral CD4+ and CD8+ T cell subsets of T cell receptor (TcR) α chain‐transgenic mice. This analysis demonstrates that a limited repertoire of TcR β chains are co‐expressed with the transgenic α chain. Most importantly, ...