Damage control, rather than unresponsiveness, effected by protective DX5+ T cells in autoimmune diabetes The progression of is regulated. We examined here the cellular controls exerted on disease that developed in the BDC2.5 T cell receptor-. We found that all... A Gonzalez,I Andre-Schmutz,C ...
T cell receptor transgenic (TCR-Tg) mice specific for the arthritogenic 5/4E8 epitope in the G1 domain of cartilage proteoglycan were generated and back-crossed into arthritis-prone BALB/c background. Although more than 90% of CD4+ T cells of all TCR-Tg lines were 5/4E8-specific, one...
a process termed memory inflation. Maintenance of high numbers of peripheral CD8 T cells requires continuous replenishment of the inflationary T cell pool. Here, we show that
This system relies on P14 T cell receptor (TCR) transgenic CD8 T cells, which recognize the gp33 epitope of the commonly used in mouse infection models lymphocytic choriomeningitis virus (LCMV; Supplementary Fig. 1A). In a typical experiment, naive P14 T cells are obtained from transgenic ...
发表文章：Infusion Product TNFα, Th2, and STAT3 Activities Are Associated with Clinical Responses to Transgenic T-cell Receptor Cell Therapy, Cancer Immunol Res（2023， IF=10.1 ）研究目的： 在癌症免疫疗法中，基于TCR-T的细胞疗法有望解决特定类型的实体瘤问题；然而，不同的患者反应和复发的可能 性...
参考文献：Nowicki TS, Peters CW, Quiros C, et al. Infusion Product TNFα, Th2, and STAT3 Activities Are Associated with Clinical Responses to Transgenic T-cell Receptor Cell Therapy. Cancer Immunol Res. 2023;11(12):1589-1597.
This was the case in models of both, CD4 and CD8 T cell mediated tumor cell rejection, also when the cancer cells were IFNγ receptor (IFNγ-R)-deficient [21,22]. In a model of large vascularized tumors in mice with selective IFNγ-R expression in individual cell types/organs, it ...
发表文章:Infusion Product TNFα, Th2, and STAT3 Activities Are Associated with Clinical Responses to Transgenic T-cell Receptor Cell Therapy, Cancer Immunol Res(2023, IF=10.1 ) 研究目的: 在癌症免疫疗法中,基于TCR-T的细胞疗法有望解决特定类型的实体瘤问题;然而,不同的患者反应和复发的可能 性表明这...
Additional genes of interest included several encoding proteins with described negative effects on T cell receptor (TCR) signaling but few described roles in CD8+ T cell exhaustion, such as Lax1, Cd101, and Pvrig, which encodes a recently described inhibitory receptor for CD112 (Murter et al....
(adapted fromBioRender.com).f, Glutarate levels in naive and 72-h activated mouse CD8+T cells. Two-tailed pairedt-test;n = 3.g, GCDH protein copy number in naive or activated CD8+T cells from P14 transgenic mice. Two-tailed unpairedt-test;n = 3. Data from the ImmPRes ...