DAPT 是一种γ-分泌酶抑制剂。 在体外抑制 Notch 信号传导。 抑制人类原代培养物中总 Aβ 和 Aβ42 的产生(IC50 值分别为 115 和 200 nM),对 APPα 和 APPβ 水平没有影响。 可透过血脑屏障。 3D 生长基质成分和脑类器官分化介质的成分。
Gamma‑secretase inhibitor DAPT suppresses glioblastoma growth via uncoupling of tumor vessel density from vessel function. Clin Exp Med 2013;13:271‑8. doi: 10.1007/s10238‑012‑0203‑8.Zou Y, Cao Y, Yue Z, Liu J (2013) Gamma-secretase inhibitor DAPT suppresses glioblastoma growth ...
1) gamma-secretase inhibitor γ泌肽酶抑制剂1. Objective To explore the inhitition effect of gamma-secretase inhibitor on Notch signaling molecules in alveolar epithelial type Ⅱ cell(AEC Ⅱ) in a heterocellular culture of AECⅡ and lung fibroblast(LF). 目的探讨γ泌肽酶抑制剂在肺泡Ⅱ型上皮...
DAPT (GSI-IX)是一种新型γ-分泌酶抑制剂，抑制HEK 293细胞中全部Aβ产量， IC50为20 nM。DAPT功能性抑制γ-分泌酶而降低HEK 293细胞中全部Aβ产量，IC50为20 nM。DAPT作用于原代培养的人神经细胞，也抑制Aβ产量，作用于全部Aβ和Aβ42时, IC50分别为115 nM和200 nM，比作用于HEK 293细胞时...
Interesting evidence indicates that sub-chronic treatment (twice-a-day for 12 days) and acute administration of semagacestat (LY-450139), a gamma-secretase inhibitor, at a dose that reduces Aβ levels produces a reduction in power of hippocampal θ activity elicited by electrical stimulation of ...
A Gamma Secretase Inhibitor is a compound that can modulate the activity of the protease complex called gamma-secretase, which is involved in the production of amyloid beta (Aβ) without completely inhibiting its function. These inhibitors are preferred as they can reduce Aβ production without dis...
administration of a gamma-secretase inhibitor, N-[N-(3,5-difluorophenacetyl)-l-alanyl]-S-phenylglycine t-butyl ester (DAPT), to young PDAPP mic... Lanz,A T. - 《Journal of Pharmacology & Experimental Therapeutics》 被引量: 422发表: 2003年 Modulation of gamma-secretase reduces beta-...
(wt)-γ-secretase could be inhibited by γ-secretase inhibitor DAPT in a dose dependant manner and prevented formation of AICD (top panel), Aβ (middle panel, run on the same gel) and NICD (bottom panel). (C) Cell free assay setup with PS1(Δ9) gave rise to AICD (lane 2 top ...
A method of reducing a subject's plasma triglyceride level, comprising administering to a subject in need thereof a gamma-secretase inhibitor in an amount effective to reduce the subject's plasma triglyceride level.Inventors: Pajvani, Utpal (Leonia, NJ, US) Application...
The administration of the γ-secretase inhibitor DAPT reduces the amount of PTS damage by reducing the level of apoptotic cell death in the peri-infarction area. Here, we showed that C- and N-terminal fragments of APP are found not only in neurons but also in astrocytes after PTS. PTS ...