DAPT司马西特Avagacestat (BMS-708163)MK-0752YO01027N1-[(7S)-6,7-二氢-6-氧代-5H-二苯并[B,D]氮杂卓-7-基]-2,2-二甲基-N3-(2,2,3,3,3-五氟丙基)丙二酰胺(AS)-N-[(1S)-2-[[(7S)-6,7-二氢-5-甲基-6-氧代-5H-二苯并[B,D]氮杂卓-7-基]氨基]-1-甲基-2-氧代乙基]-3,...
DAPT 是一种γ-分泌酶抑制剂。 在体外抑制 Notch 信号传导。 抑制人类原代培养物中总 Aβ 和 Aβ42 的产生(IC50 值分别为 115 和 200 nM),对 APPα 和 APPβ 水平没有影响。 可透过血脑屏障。 3D 生长基质成分和脑类器官分化介质的成分。
DAPT (GSI-IX)是一种新型γ-分泌酶抑制剂，抑制HEK 293细胞中全部Aβ产量， IC50为20 nM。DAPT功能性抑制γ-分泌酶而降低HEK 293细胞中全部Aβ产量，IC50为20 nM。DAPT作用于原代培养的人神经细胞，也抑制Aβ产量，作用于全部Aβ和Aβ42时, IC50分别为115 nM和200 nM，比作用于HEK 293细胞时...
Gamma‑secretase inhibitor DAPT suppresses glioblastoma growth via uncoupling of tumor vessel density from vessel function. Clin Exp Med 2013;13:271‑8. doi: 10.1007/s10238‑012‑0203‑8.Zou Y, Cao Y, Yue Z, Liu J (2013) Gamma-secretase inhibitor DAPT suppresses glioblastoma growth ...
相关产品:Bioactive Compound Library Plus | Neuronal Signaling Compound Library | Stem Cell Signaling Compound Library | Anti-Aging Compound Library | Chemical Probe Library | Anti-Alzheimer's Disease Compound Library | DAPT | RO4929097 | YO-01027 | LY-411575 | Crenigacestat | Nirogacestat | Co...
ChIP assay on the HES1 promoter using the indicated antibodies following treatment of OE33 and 786-0 cells with DAPT (15 μM), IMR-1 (25 μM), or vehicle (DMSO) using GAPDH as loading control. (Only for Reference) 化学信息 分子量353.41 ...
相关产品 Valproic acid sodium salt | Tangeretin | DAPT | Valproic Acid | RO7185876 | Gossypolone | HDAC6-IN-9 | Carvacrol | FLI-06 | CB-103 | Aβ42-IN-2 | IMR-1A 相关库 经典已知活性库 | 已知活性化合物库 | 神经信号分子库 | 神经退行性疾病化合物库 N-[3-methoxy-4-(4-methylimid...
Behavioral studies are also scarce with only one study indicating positive cognitive effects of a peptidomimetic compound (DAPT). -Secretase inhibitors may cause abnormalities in the gastrointestinal tract, thymus and spleen in rodents. These toxic effects are likely due to inhibition of Notch cleavage...
The CAS Registry Number for DAPT is 208255-80-5. The structure of DAPT is: As used herein, “BMS-906024” refers to bis(fluoroalkyl)-1,4-benzodiazepinone. The CAS Registry Number for BMS-906024 is 1401066-79-2. The structure of BMS-906024 is: As used herein, dibenzazepine or “YO-...
γ-分泌酶抑制剂DAPT 1. γ-secretase inhibitor DAPT suppresses the proliferation of Jurkat T cells γ-分泌酶抑制剂DAPT抑制Jurkat T细胞增殖 更多例句>> 5) Dipeptidase inhibitor 肽酶抑制剂 例句>> 6) secretase inhibitor 分泌酶抑制剂 1. 00 μg·mL~(-1)),β-secretase inhibitor(S4562,100. ...