抑制人类原代培养物中总 Aβ 和 Aβ42 的产生(IC50 值分别为 115 和 200 nM),对 APPα 和 APPβ 水平没有影响。 可透过血脑屏障。 3D 生长基质成分和脑类器官分化介质的成分。图1.DAPT化学结构DAPT基础信息产品名:DAPT;γ-分泌酶抑制剂;γ分泌酶抑制剂;gamma-Secretase inhibitor;gamma Secretase inhibitor...
Zou Y, Cao Y, Yue Z, Liu J (2013) Gamma-secretase inhibitor DAPT suppresses glioblastoma growth via uncoupling of tumor vessel density from vessel function. Clin Exp Med 13(4):271–278Yuhui Zou, Yiqun Cao, Zhijian Yue, Jianmin Liu. (2012) Gamma-secretase inhibitor DAPT suppresses ...
CAS号208255-80-5Ethanol 50 mg/mL 储存条件3年 -20°C 粉末状 生物活性 DAPT (GSI-IX)是一种新型γ-分泌酶抑制剂，抑制HEK 293细胞中全部Aβ产量， IC50为20 nM。DAPT功能性抑制γ-分泌酶而降低HEK 293细胞中全部Aβ产量，IC50为20 nM。DAPT作用于原代培养的人神经细胞，也抑制Aβ产量，...
Gold nanoparticlesVitamin CCancer stem cells (CSCs) are responsible for tumor initiation, drug resistance and cancer relapses. The Notch pathway regulates CSCs, and it is essential for the self-renewal and maintenance of CSCs. Gamma-secretase inhibitor such as DAPT, reduces the CSCs by inhibiting...
The effect of gamma-secretase Inhibitor (DAPT) on proliferation and apoptosis of colorectal cancer cell line HT29Liao, WDLi, GHChen, J.<Lv, NHWang, CWWu, Q
Enhanced delivery of gamma-secretase inhibitor DAPT into the brain via an ascorbic acid mediated strategy. Quelever, G,P Kachidian,C. Melon,C. Garino,Y. Laras,N. Pietrancosta,M. Sheha,J.L. Kraus. Organic & Biomolecular Chemistry . 2005...
2006 . C-terminal fragment of presenilin is the molecular target of a dipeptidic gamma-secretase-specific inhibitor DAPT (N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester) . J Biol Chem 281 : 14670 – 14676 ....