Beyond γ-secretase activity: The multifunctional nature of presenilins in cell signalling pathways. Cell Signal. 2016, 28, 1-11. [CrossRef] [PubMed]Duggan, S.P.; McCarthy, J.V. Beyond γ-secretase activity: The multifunctional nature of presenilins in cell signalling pathways. Cell. ...
γ-Secretase Activity Is Present in Rafts but Is Not Cholesterol-Dependent γ-secretase activity is present in rafts but is not cholesterol-dependent. Biochemistry. 42: 3977-13986.Wada, S. et al., “γ-Secretase Activity is... Satoko,Wada,Maho,... - 《Biochemistry》 被引量: 136发表: ...
Moreover, disruption of the expression of Psn by double-stranded RNA-mediated interference completely abolished the γ-secretase activity in S2 cells. Surprisingly, γ-secretase activity dependent on wild-type Psn was associated with a drastic overproduction of Aβ1–42 from human βAPP in N2a ...
TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity. Nature 440, 1208–1212 (2006). Article ADS CAS Google Scholar Zhou, S. & Zhou, H., Walian PJ, Jap BK. Regulation of gamma-secretase activity in Alzheimer’s disease. Biochemistry 46,...
This finding suggests that PS1 may serve other biological functions in addition to that associated with its gamma-secretase activity. Furthermore, the PS1 gamma-secretase complex and the PS2 gamma-secretase complex activities can be discriminated on the basis of their susceptibility to inhibition by ...
Phase I will assess the feasibility of gamma-secretase activity assays to monitor inhibition by commercially available protease inhibitors; this Phase I study will also determine whether distinct y-secretases can be separated for more selective drug screening. Results from Phase I will be used as ...
Jin S M,Cho H J,Jung M W,et al.DNA damage-inducingagent-elicited gamma-secretase activity is dependent on Bax/Bcl-2pathway but not on caspase cascades.Cell Death and Differentiation. 2007Jin SM, Cho HJ, Jung MW, Mook-Jung I. DNA damage-inducing agent-elicited gamma-secretase activity ...
Finally, our results indicate that interferon-gamma stimulates gamma-secretase-dependent cleavages on phagosomes and that gamma-secretase activity may be involved in the phagocytic response of macrophages to inflammatory cytokines. 展开 关键词: Secretase Functional Component Phagosomes DOI: 10.1074/jbc...
It is intended, as compounds inhibiting the &gammad -secretase activity, compounds having an amino acid sequence which comprises at least 3 consecutive amino acids including the 11-th Leu in the amino acid sequence Val-Val-Ile-Ala-Thr-Val-Ile-Val-Ile-Thr-Leu-Val-Met-Leu-Lys-Lys-Lys, has...
γ-Secretase activity requires the formation of a stable, high-molecular-mass protein complexthat, in addition to the endoproteolysed fragmented form of presenilin, contains essential cofactors including nicastrin, APH-1 (refs) and PEN-2 (refs,). However, the role of each protein in complex ...