Mutations of the gamma﹕ecretase gene complex, which is essential in the activation of Notch signalling pathways were shown in some families with HS and in a few sporadic cases. Although an imbalance in Notch signalling is implicated in the pathogenesis, the exact mechanism of HS development is...
ArticleADSCASGoogle Scholar Lefranc-Jullien, S., Sunyach, C. & Checler, F. APPε, the ε-secretase-derived N-terminal product of the β-amyloid precursor protein, behaves as a type I protein and undergoes α-, β-, and γ-secretase cleavages.J. Neurochem.97, 807–817 (2006) Article...
MK-0752, known as 3-[4-(4-chlorophenyl) sulfonyl-4-(2,5-difluorophenyl)cyclohexyl]propanoic acid, is a potent oral inhibitor of γ-secretase. In a phase I study involving 103 patients with advanced solid tumor, preliminary antitumor efficacy was observed via modulation of Notch gene signature...
A plasmid encoding PS1wt was cloned into pcDNA3.1 vector (Addgene). The GLT-1 encoding sequence was subcloned into pcDNA6 V5 Myc (Thermo Fisher Scientific). Alanine scanning on PS1wt and GLT-1wt was performed by cloning with primers provided by Twist Bioscience. Alanine scanning strategy The...
The Gene Encoding Nicastrin, a Major g -Secretase Component, Modifies Risk for Familial Early-Onset Alzheimer Disease in a Dutch Population-Based Sample. Presents a study on the role of the gene encoding nicastrin (NCSTN), a major gamma -secretase component, in modifying the risk for familial ...
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The present invention relates to gene signatures and gene expression profiles which may provide predictive molecular tools for clinical applications. The invention also relates to methods of predicting the sensitivity of cancers in a human subject to specific anticancer drugs, particularly gamma secretase ...
enzyme activity. a notch intracellular domain responsive reporter gene, and the constitutive gamma-secretase notch substrate, notchΔe, were stably introduced into chosw cells in a two-step process. chosw cells were first stably transfected to express a nicd responsive luciferase reporter gene ...
1.Bakar N A, Ibrahim W N W, Zulkiflli A R, et al.Embryonic mercury exposure in zebrafish: Alteration of metabolites and gene expression, related to visual and behavioral impairments.Ecotoxicology and Environmental Safety.2023, 256: 114862....
Gene/Insert插入基因名称:Gamma-secretase subunits PEN-2 and presenilin1 wt (Homo sapiens)Cat#货号: BioVector-0207803Map图谱:Sequence序列:Contact BioVector@163.comPromoter启动子:Insert/Gene Type:Bacterial resistance原核抗性:Selection Marker真核筛选标记:Reporter/Tag荧光报告基因/标签:Species种属:Genetic ...