AsymmetricPalladiumCatalysisThis Letter describes the first catalytic asymmetric α-allylic alkylation of thioamides. By using 5mol% Pd-(R)-DM-BINAP complex as the chiral catalyst, various thioamides were efficiently α-allylic alkylated with 1,3-diarylallyl carbonates under mild conditions, affording...
The palladium-catalyzed asymmetric allylic alkylation (Pd-AAA) reaction has played a key role in creating such stereocenters and has allowed researchers to synthesize a vast number of biologically potent natural products. However, synthetic methodologies to access compounds containing α-aryl groups to ...
Direct catalytic intermolecular α-allylic alkylation of aldehydes by combination of transition-metal and organocatalysis. Angew. Chem. Int. Ed. 2006, 45, 1952-1956.Ibrahem, I,Cordova, A.Direct Catalytic Intermolecular α-Allylic Alkylation of Aldehydes by Combination of Transition-Metal and ...
Alkylation of allylic derivatives. 5. Loss of double-bond configuration associated with .alpha.-alkylation of allylic carboxylates with dialkylcuprates. Harlan L. Goering,Steven S. Kantner. Journal of Organic Chemistry . 1983Harlan L. Goering,Steven S. Kantner.Alkylation of allylic derivatives. 5...
Xu Liwen,Gao Guang,Gu Fenglei,et al.Dual amine-and br nsted acid-catalyzed α-allylic alkylation of aldehydes[J].Advanced Synthesis & Catalysis,2010,352(9):1441-1445.Xu Liwen,Gao Guang,Gu Fenglei. Dual amine-and br nsted acid-catalyzed α-allylic alkylation of aldehydes[J].Advanced ...
allylic alkylationA synthetically useful approach for the synthesis of functionalized alpha, alpha-disubstituted alpha-amino acid derivatives via palladium-catalyzed 1,7 addition of readily available aldimine esters to vinylcyclopropanes is reported. This methodology was operated under mild conditions, ...
alkylation, arylation, dealkylation, dearylation, C‐acylation, olefinationpolyphenylalkane derivativesfused 6,6,6‐ring systemsPhotoallylation of α-diketones, e.g. (I) or (X), with the allylic stannanes (II) or (VII) yields the corresponding homoallylic alcohols as shown in the reaction ...
ENANTIOSELECTIVE SYNTHESIS OF ALPHA-QUATERNARY MANNICH ADDUCTS BY PALLADIUM-CATALYZED ALLYLIC ALKYLATIONThis invention provides enantioenriched Mannich adducts with quaternary stereogenic centers and novel methods of preparing the compounds. Methods include the method for the preparation of a compound of formula...
ENANTIOSELECTIVE SYNTHESIS OF alpha-QUATERNARY MANNICH ADDUCTS BY PALLADIUM-CATALYZED ALLYLIC ALKYLATIONThis invention provides enantioenriched Mannich adducts with quaternary stereogenic centers and novel methods of preparing the compounds. Methods include the method for the preparation of a compound of formula...
Methods include the method for the preparation of a compound of formula (I): comprising treating a compound of formula (II): with a transition metal catalyst under alkylation conditions.Stoltz, Brian M.Numajiri, YoshitakaPritchett, Beau P....