Regioselective arene CH bond alkylation is a powerful tool in synthetic chemistry, yet subject to many challenges. Herein, we report the meta-CH bond alkylation of aromatics bearing N-directing groups using (hetero)aromatic epoxides as alkylating agents. This method results in complete regioselectivity...
This is the first example of a metal-catalyzed highly meta-selective direct C—H bond alkylation.doi:10.1002/chin.201338147Hofmann, NoraAckermann, LutzChemInformHofmann, N.; Ackermann, L. Meta-selective C-H bond alkylation with secondary alkyl halides. J. Am. Chem. Soc. 2013, 135, 5877-588...
arenesalkenylationalkylationC−H activationpalladiumTo expand the scope of meta‐functionalization, a pyrimidine‐based template effective for the formation of β‐aryl aldehydes and ketones, using allyl alcohols, by meta‐C?H activation of benzylsulfonyl esters is described. In addition, α,β‐...
alkylation catalyst; (2) allowing the cumene and propylene in the feed stream to react together to produce a first mixture of para-diisopropylbenzene and meta-diisopropylbenzene; (3) fractionally distilling the mixture of para-diisopropylbenzene and meta-diisopropylbenzene in a fractional ...
Their preparation involves an alkylation of an aromatic ring, for example, such as a Friedel-Crafts alkylation with 4-bromomethyl-3,5-dibromo-2,6-dimethylphenol or with 4-hydroxymethyl-3,5-dibromo-2,6-dimethylphenol.メンドザアベルフリッツ...
A process for producing an alkylated aromatic product having high selectivity to the thermodynamically preferred isomer by contacting meta- xylene and a C.sub.13 to C.sub.20 alpha-olefinic compound at a reaction temperature of about 40° to about 80° C. in the presence of a catalyst ...
Their preparation involves an alkylation of an aromatic ring, for example, such as a Friedel-Crafts alkylation with 4-bromomethyl-3,5-dibromo-2,6-dimethylphenol or with 4-hydroxymethyl-3,5-dibromo-2,6-dimethylphenol.
The isopropylation of large molecules like meta DIPB (Diisopropylbenzene) is a reaction wherein the formation of isomeric DIPB s & isomeric TIPB s (Triisopropylbenzene) signify the pore dimensions and the structural properties. Thus isomerization is the major reaction in Hß, whereas isomerization...
This was used in the enantioselective meta-C-H arylation of benzylamines, as well as the arylation and alkylation of homobenzylamines. The enantioselectivities obtained using the chiral transient mediator are comparable across different classes of substrates containing either neutral 蟽-donor or anionic...
Here, we introduce resonant mixing as an efficient method for-C–H alkylation of arenes using a Ru-catalyst, avoiding the need for bulk solvents, external temperature, or light. The described methodology is highly rapid, enabling multigram-scale synthesis of-alkylation products within a short ...