A tandem α-alkylation/asymmetric transfer hydrogenation of acetophenones with primary alcohols, mediated by a single ruthenium catalyst, is described. Under optimized reaction conditions and with use of [Ru(p-cymene)Cl2]2 in combination with an amino acid hydroxyamide ligand, the chiral secondary...
Enrico EmerPier Giorgio CozziJohn Wiley & Sons, LtdGualandi, A.; Petruzziello, D.; Emer, E.; Cozzi, P.G. Alpha-alkylation by SN1-type reactions. In Comprehensive Enantioselective Organocatalysis: Catalysts, Reactions, and Applications, 1st ed.; Dalko, P.I., Ed.; Wiley-VCH: Weinheim, ...
Being direct: A Brønsted acid catalyzed α alkylation of ketones is described. The phosphoric acid 1 promotes this reaction to afford the desired products with high yields, high diastereoselectivities, and good to excellent enantioselectivites.Angewandte Chemie International EditionLiu SongProf. ...
摘要: A process for alkylating the alpha position of the 8-acyl side chain in mevinolin and analogs thereof is disclosed. The process proceeds with a single charge of base and alkyl halide to give products with a pharmaceutically acceptable purity....
摘要: Enantiomerically pure alpha-substituted beta-amino esters were prepared from natural L-alpha-amino acids through Arndt-Eistert homologation and diastercoselective alpha-alkylation.年份: 2002 收藏 引用 批量引用 报错 分享 全部来源 求助全文 ResearchGate ir.pku.edu.cn 相似文献 参考文献Asymmetric ...
United States Patent US4731497 Note: If you have problems viewing the PDF, please make sure you have the latest version ofAdobe Acrobat. Back to full text
Highly stereoselective alpha-hydroxyalkylation/chlorination of alpha,beta-acetylenic ketones - An efficient approach to beta-halogeno Baylis-Hillman adductsHighly stereoselective alpha-hydroxyalkylation/chlorination of alpha,beta-acetylenic ketones - An efficient approach to beta-halogeno Bayl...
(thio)urea alpha-aminoalkylation with isobut - yraldehyde and sec aminesN,N'-disubstd. (thio)ureas, useful as vulcanisation accelerators, rubber stabilisers, textile assistants and lubricating oil additives, have formula X=C(NH-CH(CH-(CH3)2)NRR')2 (where R and R' are 1-4C alkyl or...
3-piperidinol N-alpha-carbanion intermediate 3-piperidinol N-alpha-carbanion intermediate B 3-piperidinol N-alpha-carbanion B lithium naphthanelide (LN)-mediated reductive lithiation alpha-hydroxyalkylation 引用走势 2011 被引量:6 站内活动
摘要: A diastereo specific method for the synthesis of individual enantiomers of 1S,5R- and 1R,5S-glycoluriles has been developed based on the alpha-ureidoalkylation of (S)/(R)-N-carbarnoyl-alpha-amino acids with 4,5-dihydroxyimidazolidin-2-one. 关键词: AMINO-ACIDS 年份: 2004 收藏...