Under these typical N‐alkylation reaction conditions, hydantoin alkyl acetates were also isolated, along with the expected N‐alkylated products. Additional experiments were also performed to investigate the role of N,N‐dimethylformamide in the transesterification reaction and a possible mechanism is ...
Enantioselective Reductive N-Cyclization–Alkylation Reaction of Alkene-Tethered Oxime Esters and Alkyl Iodides by Nickel Catalysis. Xue-Gong Jia, Qi-Wei Yao, Xing-Zhong Shu*.J. Am. Chem. Soc.2022, https://doi.org/10.1021/ja...
Neda I, Melnicky C, Vollbrecht A, Schmutzler R. An Unusual N-Alkylation Reaction During the Oxidative Addition of Hexafluoroacetone and Tetrachloro-o-benzoquinone to P-Bis(2-chloroethyl) amino-Substituted λ3P-Compounds. Synthesis, 1996, (4): 473~474...
Table 1. Optimization of the Reaction Conditions (图片来源:J. Am. Chem. Soc.) 在最优反应条件下,作者进行了反应底物的普适性研究。反应可以兼容不同类型的碘代烷烃(Table 2)。溴代芳烃、烷基氯、Ac和TBS保护的醇、酯、酮、酰胺、烷基硅醚、烯烃等官能团均能与反应催化体系兼容。反应较好的官能团兼容性为...
aReaction conditions:1(0.1 mmol),2(0.5 mmol), PA (0.1 mmol) and NH4PF6(0.5 mmol), THF : H2O (2 : 1, 3 mL), r.t, in air, undivided cell (RVCanode and Ni foam cathode) at constant current (10 mA) for 120 min. Isolated yields.b...
Although such ionic glycosylation strategies can effectively form O-glycosides, their use in N-glycoside synthesis is often plagued by the subdued reactivity of N-nucleophiles under the acidic reaction conditions required for glycosyl donor activation. Exploration of the reactivity of glycosyl radical ...
Reaction conditions: benzaldehyde (1a), N-benzyl aniline (3a), and indole (4a) were taken in 1:1.2:1 ratio. b Isolated yield. c Amberlite IR-120 resin was used as catalyst. The recyclability of the Amberlite IRA-400 Cl resin catalyst has been studied and the results are shown in Table...
amine (redirected fromN-alkylation) Thesaurus Medical Encyclopedia a·mine (ə-mēn′, ăm′ēn) n. Any of a group of organic compounds of nitrogen, such as ethylamine, C2H5NH2, that may be considered ammonia derivatives in which one or more hydrogen atoms have been replaced by a hydrocar...
Synthetic reaction by complex catalyst Ⅲ.Copper catalyzed n-alkylation of amine with diazoalkie[J].{H}Tetrahedron Letters,1966,(49):6131-6134.SAEGUSA T,ITO Y,KOBAYASHI S,et al.Synthetic re- action by complex catalystⅢ .Copper catalyzed n-alkylation of amine with diazoalkie[J].Tetrahedron ...
2) N-alkylation reaction N-烷基化反应 1. The methods for preparing these heterocyclic intermediates,including the N-alkylation reaction condition are researched. 合成了化合物1-烷基-3-取代-4-氨基吡唑-5-羧酸酯(1)和1-烷基-3-取代-5-氨基吡唑-4-羧酸酯(2),并对重要中间体3-取代-4-硝基吡唑-...