The N-alkylation reaction of N-benzoyl 5-(aminomethyl)tetrazole (5-AMT) with benzyl bromide was carried out in the presence of K2CO3 as a base. Two separable regioisomers were obtained, thus their purification led to determine the proportion of each of them, and their structures were ...
reaction conditions, using microwave irradiation, the amounts of both14and15increased (entry 2). As usual, the best results were achieved without the drying agent (CaCl2) and by utilising high-purity PC under MW conditions (entry 3). As expected, in all cases, the 1N-alkylation reaction (...
MDPI and ACS Style Zhang, X.; Zhang, Q.; Reng, J.; Lin, Y.; Tang, Y.; Liu, G.; Wang, P.; Lu, G.-P. N, S Co-Coordinated Zinc Single-Atom Catalysts for N-Alkylation of Aromatic Amines with Alcohols: The Role of S-Doping in the Reaction. Nanomaterials 2023, 13, 445. htt...
Another important N-dealkylation reaction in living systems is the repair of alkylated DNA, which eliminates the alkylation damage at nitrogen atoms in nucleobases in the DNA structure upon the exposure of living cells to 3alkylating agents. If the N-alkylated modifications in the DNA structure are...
The reaction was conducted for 17 h at 0 ◦C–rt. Purification of the residue by column chromatography (hexane/AcOEt = 10 and then 3) gave 1d (804 mg, quant). 1d: White solid; mp 161–163 ◦C; IR (neat) 3275, 1331, 1157 cm−1; 1H NMR (400 MHz, CDCl3) δ: 7.56 (2H...
This review covers the asymmetric N-alkylation of indolines, isatins and 4,7-dihydroindoles, followed by a redox reaction, which provides the corresponding N-alkylated indoles (Scheme 2, III, IV and V respectively). Scheme 2. Strategies for the enantioselective N-functionalization of indoles. ...
Upon completion of the reaction, the mixture was poured over ice cold saturated brine. A 10% sulfuric acid solution was added dropwise until complete precipitation of the product had occurred. The resulted solid was filtered under vacuum and dried. The remaining residue was crystallized twice from...
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Share and Cite MDPI and ACS Style Esnault, C.; Schrama, D.; Houben, R.; Guyétant, S.; Desgranges, A....
Scheme 1. Reaction conditions for the alkylation of triethylamine with 1-(4-bromobutyl)-1H-pyrrole 1 and ion exchange of the resulting bromide with sodium perchlorate. The whole reaction sequence starting from 1H-pyrrole is chromatography free, atom-economic and produces the title product in very...
MDPI and ACS Style Mekheimer, R.A.; Al-Sheikh, M.A.; Medrasi, H.Y.; Alsofyani, N.H.H. A Novel Synthesis of Highly Functionalized Pyridines by a One-Pot, Three-Component Tandem Reaction of Aldehydes, Malononitrile and N-Alkyl-2-cyanoacetamides under Microwave Irradiation. Molecules 2018...