the zinc finger (ZF) domain of NEMO for NF-κB activation in response to genotoxic stress.Using a somatic genetic reconstitution approach, I uncovered a new function of the ZF as a novel histone H2B binding domain that appears to be critical for NF-κB activation in response to DNA damage....
Expression of functional zinc finger domain of human poly(ADP-ribose)polymerase in E. coli. 来自 国家科技图书文献中心 喜欢 0 阅读量: 19 作者:G Gradwohl,JMD Murcia,M Molinete,F Simonin,GD Murcia 摘要: Author information: (1)Institut de Biologie Moleculaire et Cellulaire du CNRS, Laboratoire ...
The zinc finger motif was used as a vehicle for the initial discovery of Ikaros in the context of T-cell differentiation and has been central to all subsequent analyses of Ikaros function.The Ikaros gene is alternately spliced to produce several isoforms that confer diversity of function and cons...
The action of Pb on , , and suggests that it can also target other cellular proteins that contain the zinc finger motif and reveals this protein domain as a potential mediator for Pb-induced alterations in protein function. Thus by specifically targeting (), Pb is able to produce multiple ...
Expansion of multi-C2H2 domain zinc finger (ZNF) genes, including the Krüppel-associated box (KRAB) subfamily, paralleled the evolution of tetrapodes, particularly in mammalian lineages. Advances in their cataloging and characterization suggest that the functions of the KRAB-ZNF gene family contributed...
摘要: The disclosure describes artificial chimeric transcription factors that include at least one zinc finger domain and that can regulate cellular differentiation, for example, a neuronal cell phenotype or an osteoblast phenotype.收藏 引用 批量引用 报错 分享 ...
Cys2His2 zinc finger (ZF) domains engineered to bind specific target sequences in the genome provide an effective strategy for programmable regulation of gene expression, with many potential therapeutic applications. However, the structurally intricate e
The pro1 gene, controlling fruiting body development in the homothallic ascomycete Sordaria macrospora, encodes a C 6 zinc finger protein with a typical DNA binding domain of GAL4-like C 6 zinc finger proteins as well as a putative nuclear targeting signal. In the corresponding mutant pro1, ...
Proteins containing the zinc finger domain(s) are named zinc finger proteins (ZFPs), one of the largest classes of transcription factors in eukaryotic genomes. A large number of ZFPs have been studied and many of them were found to be involved in regulating normal growth and development of ...
The tandem zinc finger (TZF) domain of the protein TIS11d binds to the class II AU-rich element (ARE) in the 3′ untranslated region (3′ UTR) of target mRNAs and promotes their deadenylation and degradation. The NMR structure of the TIS11d TZF domain bound to the RNA sequence 5′-...