Wnt/beta-catenin signalling in prostate cancer. Nat Rev Urol. 2012 Jun 19. [Epub ahead of print].R. M. Kypta and J. Waxman, "Wnt/beta-catenin signalling in prostate cancer," Nature Reviews Urology, vol. 9, pp. 418-428, 2012....
In addition, β-catenin associates with the androgen receptor, a key regulator of prostate growth that drives prostate cancer progression. Wnt/β-catenin signalling can be controlled by secreted Wnt antagonists, many of which are downregulated in cancer. Activation of the Wnt/β-catenin pathway has...
Inhibition of tankyrases induces Axin stabilization and blocks Wnt signalling in breast cancer cells PLoS One, 7 (2012), p. e48670 CrossrefView in ScopusGoogle Scholar [124] F. Takahashi-Yanaga, T. Sasaguri Drug development targeting the glycogen synthase kinase-3beta (GSK-3beta)-mediated si...
Wnt signalling in stem cells and cancer. Nature. 2005;434(7035):843. Article CAS PubMed Google Scholar Hart MJ. de los Santos R, Albert IN, Rubinfeld B, Polakis P: downregulation of β-catenin by human Axin and its association with the APC tumor suppressor, β-catenin and GSK3β. ...
TCF-1 and LEF-1 help launch the T(FH) program.###Wnt/-catenin signalling in prostate cancer.###TCF1 and LEF1 act as T-cell intrinsic HTLV-1 antagonists by targeting Tax.###Wnt signaling transcription factors TCF-1 and LEF-1 are upregulated in malignant astrocytic brain tumors.###Syst...
Fig. 2 Expression of hnRNPK in breast cancer tissues and cells A: Western blot was used to verify the expression of hnRNPK in breast cancer tissue; B: Determination of hnRNPK protein expression levels in normal breas...
In spite of significant advancements in diagnosis and treatment, cancer is still a big threat to society. This is the second most common disease for maximum deaths in the world and it accounts for about 7% deaths in India. Prostate cancer is the most common cancer in males inwestern countries...
Wnt3A activates canonical Wnt signalling in acute lymphoblastic leukaemia (ALL) cells and inhibits the proliferation of B-ALL cell lines. Br J Haematol. 2007;136(3):400–13. Article CAS PubMed Google Scholar Zimmerman ZF, Kulikauskas RM, Bomsztyk K, Moon RT, Chien AJ. Activation of ...
Wnt/β-catenin signaling in cancers and targeted therapies Article Open access 30 August 2021 Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities Article Open access 03 January 2022 Targeting TGFβ signal transduction for cancer therapy Article Open access 08...
WNT signalling pathways as therapeutic targets in cancer. Nat Rev Cancer 2013; 13: 11–26. CAS PubMed Google Scholar Wang Y . Wnt/Planar cell polarity signaling: a new paradigm for cancer therapy. Mol Cancer Ther 2009; 8: 2103–2109. CAS PubMed Google Scholar Katoh M . WNT/PCP ...