主要内容有Wnt通路在kegg通路中的位置、简要结构、Wnt蛋白家族及其胞外分泌过程、Wnt受体及相关调节,在下期文章中将分享的是Wnt信号通路中经典Wnt/β-catenin信号通路的信号传导过程、非经典的Wnt/PCP通路、非经典的Wnt/Ca2+离子通路。
主要内容有Wnt通路在kegg通路中的位置、简要结构、Wnt蛋白家族及其胞外分泌过程、Wnt受体及相关调节,在下期文章中将分享的是Wnt信号通路中经典Wnt/β-catenin信号通路的信号传导过程、非经典的Wnt/PCP通路、非经典的Wnt/Ca2+离子通路。
A recent genome-wide study and KEGG pathway analysis of methylated genes showed that Wnt/β-catenin pathway was the top scored pathway of the methylomes of NPC primary tumors.10The self-renewal property of the NPC stem-like cells has previously been demonstrated to be regulated by the physiologi...
本研究表明,从榆耳纯化的多糖GIPS可以抑制结肠癌的生长,这可能是通过抑制Wnt/ β-连锁蛋白信号通路实现的。 Anti-colon cancer activity of water-soluble polysaccharides extracted from Gloeostereum incarnatum via Wnt/β-catenin signaling pathway Jiawei Hea,b, Anhui Yanga, Xuyu Zhaoa, Yang Liua, Shuyan Li...
近年来,克氏原螯虾(Procambarus clarkii)作 为一种无脊椎动物的模式生物,其天然抗病毒免疫 涉及 Wnt 信号通路已被证实.Du 等[87- 88]根据克氏 原螯虾转录组测序结果,通过对实验组(WSSV 侵染) 与对照组的差异表达基因进行 KEGG 通路分析,筛 选出一些与天然免疫相关的经典信号通路,如 Wnt 信号通路,JAK-STAT ...
结论Wnt信号通路可能是调控结肠癌演变过程的重要信号通路之一【Abstract】ObjectiveTostudythechangesandrolesofWntsignalingpathwayincoloncancerTheHumanGenomeU133PlusArraywereusedtoanalyzegeneexpressionprofilesincoloncancerandnormalgenesrelatedtoWntsignalingpathwaywereselectedthroughgenechipdataThekeygenesrelatedtoWntsignaling...
【Key words】 Colon cancer; Wnt signaling pathway; Genechip 结肠癌是我国常见恶性肿瘤之一,早期症状不明显,无特异性,晚期表现为大便习惯改变,早期诊断、有效地判断病情的发展、评估预后对降低结肠癌病死率十分重要。而进一步深入研究结肠癌发生机制,是更好防治结肠癌的必要基础。近年研究发现Wnt(果蝇无翅基因wingless...
KEGG 的Wnt signaling pathway - Homo sapiens (human) 其他的非典型Wnt通路 The term non-canonical pathway refers to a group of wnt-dependent signalling pathways which do not lead to the cytoplasmic stabilization of soluble β-catenin. Two of these pathways have been well characterized: the planar ...
Biological and molecular functions, signaling pathways and protein-protein interactions were analyzed using free-access databases: PubMed, PANTHER, Gene Ontology, Swiss-Prot and KEGG. Protein-protein interactions (PPIs) were analyzed using the STRING database (version 10). Results: There were ...
进一步采用京都基因和基因组百科全书数据库(KEGG)进行通路分析发现,鼻咽癌中Wnt、TGF-β、Hedgehog和MAPK等关键信号通路被DNA甲基化破坏[52]。如前文所述,已有研究证实DNA甲基化可通过Wnt和MAPK通路影响鼻咽癌的侵袭与转移,然而,尚未有研究证明DNA甲基化可通过TGF-β和Hedgehog通路影响鼻咽癌的侵袭与转移。此外,尚有诸多...