brain-wide mappingc-Fosmaternal separationneuronal activationultrasonic vocalizationFOS EXPRESSIONCOMMUNICATIONTRANSCRIPTIONMEMORYGENENeonatal mice emit ultrasonic vocalizations (USVs) when separated from their mothers. Since the USVs attract their mothers' attention and trigger maternal retrieval, they are ...
Mapping patterns of c-fos expression in the central nervous system after seizure. Science 237, 192–197 (1987). Article CAS PubMed Google Scholar Cancedda, L. et al. Patterned vision causes CRE-mediated gene expression in the visual cortex through PKA and ERK. J. Neurosci. 23, 7012–...
An additional method that allows for the evaluation of behavior-induced neural activity in rodents is based on the use of genes regulated by neuronal activity, such as Fos. Fos is a transcription factor induced by neural activity resulting from emotional arousal or sensory signals [190,191]. Imm...
distributions, whereas spatial organization of cells showed a higher level of regularity in the telencephalic regions, such as the layer-specific distribution of cortical neurons. The comprehensive mapping of spatial distributions of the transcriptionally distinct neuronal cell types allowed us to partition ...
compared to the PC group. C-Fos results highlighted the role of the prefrontal cortex,dorsal striatum, anterodorsalthalamusand CA3 in the PC group, compared to the OPC, RM5 and RM8 groups. The animals were able to find the escape platform even when only a portion of the space where the...
Amylin dosing resulted in neuronal activation as measured by an increase in c‐Fos labelled cells in 20 brain regions, altogether making up the circuitry of neuronal appetite regulation (e.g., area postrema (AP), nucleus of the solitary tract (NTS), parabrachial nucleus (PB), and central ...
Mapping accumulative whole-brain activities during environmental enrichment with manganese-enhanced magnetic resonance imagingEnriched environmentManganese-enhanced magnetic resonance imagingBrainMousec-FosDopamineAn enriched environment (EE) provides multi-dimensional stimuli to the brain. EE exposure for days to...
Whole-brain activity mappingBackground:Cortical spreading depression (CSD) is an electrophysiological event underlying migraine aura. Traditional CSD models are invasive and often cause injuries. The aim of the study was to establish a minimally invasive optogenetic CSD model and identify the active ...
We developed an automated whole-brain mapping pipeline to identify brain circuits underlying pair-bonding behavior. We identified bonding-related c-Fos induction in 68 brain regions clustered in seven major brain-wide neuronal circuits. These circuits include known regulators of bondin...
DREAMM is thus the first technique that provides simultaneously quantitative, dynamic, whole-brain and regionally unbiased, cell type-specific functional circuit mapping captured during the awake, freely moving state. DREAMM affords the unique flexibility of combining multiple strategies—molecular, viral,...