c‐Fos response was also detected in distinct nuclei across the brain that typically have not been linked with amylin signalling. In RAMP1/3 knockout amylin induced low‐level neuronal activation in seven regions, including the AP, NTS and PB, indicating the existence of RAMP1/3‐independent ...
Some of, but not all, the brain regions in the EE-treated mice showing enhanced MEMRI signal intensity had accompanying increases in c-Fos expression. The EE-treated mice were also found to have significantly increased overall amount of food consumption, decreased body weight gain and upregulated...
An additional method that allows for the evaluation of behavior-induced neural activity in rodents is based on the use of genes regulated by neuronal activity, such as Fos. Fos is a transcription factor induced by neural activity resulting from emotional arousal or sensory signals [190,191]. Imm...
DREAMM is thus the first technique that provides simultaneously quantitative, dynamic, whole-brain and regionally unbiased, cell type-specific functional circuit mapping captured during the awake, freely moving state. DREAMM affords the unique flexibility of combining multiple strategies—molecular, viral,...
mapping of the spatial organization of molecularly defined cell types in complex tissues1,23, including several brain regions (for example, refs.1,2,3,4,5,6,7,8,9,10,11). However, a comprehensive cell atlas of the whole brain is still missing. Here we imaged a panel of more than 1...
Mapping immediate early gene (IEG) expression across intact brains is becoming a popular approach for identifying the brain-wide activity patterns underlying behavior. Registering whole brains to an anatomical atlas presents a technical challenge that has predominantly been tackled using automated voxel-ba...
Using c-fos as a neural marker of pain Brain Res. Bull. (1998) View more references Cited by (7) Teratogenic effects of maternal drug abuse on developing brain and underlying neurotransmitter mechanisms 2021, NeuroToxicology Citation Excerpt : ...
. Protein-protein interaction analysis also showed that genes (e.g.,JUN,FOSandNR4A1) related to the above GO terms were at the center of the regulatory network within the genes in M3 (Supplementary Fig.5d). Furthermore, we explored the changes between gene expression and bio-indicators over...
mapping of the spatial organization of molecularly defined cell types in complex tissues1,2,3, including several brain regions (for example, refs.1,2,3,4,5,6,7,8,9,10,11). However, a comprehensive cell atlas of the whole brain is still missing. Here we imaged a panel of more than ...
Boston Terriers with central nervous system abnormalities described in the present report mimic the clinical manifestations of humans affected by severe forms of MPS I, in which progressive cerebral disease develops with depositions of the GAGs in the meninges and white matter of the brain3,4. In...