Key Points: Question: Is whole-genome sequencing (WGS) more cost-effective than whole-exome sequencing for children with suspected genetic disorders? Findings: The results of this economic evaluation of a cohort of 870 pediatric patients suggest that adopting W...
This economic evaluation estimates the cost-effectiveness of whole-genome sequencing compared with whole-exome sequencing and conventional testing in
(2013). Analysis and annotation of whole-genome or whole- exome sequencing-derived variants for clinical diagnosis. Curr Protoc Hum Genet. 18;79:unit 9.24.Elizabeth A.Worthey. Analysis and Annotation of Whole-Genome or Whole-Exome Sequencing-Derived Variants for Clinical Diagnosis. 2013:, 9.24....
Zhiming Cai and colleagues report whole-genome and whole-exome sequencing of 99 paired tumor-normal samples of transitional cell carcinoma of the bladder. They find that 32% of tumors harbor alterations in genes involved in sister chromatid cohesion, inc
Based on workflow, the global whole genome and exome market was led by the WES segment, which held a 64.92% share in 2023. The whole exome sequencing (WES) workflow begins with the extraction, isolation, and puri...
Research of these determinants has been performed in candidate gene, genome-wide association and linkage studies. Because exploration of the common variation in the genome did not explain much of the variation in the rate of aging and longevity, researchers in the field have only recently started ...
Whole genome and exome sequencing of monozygotic twins discordant for Crohn's disease. BMC Geno- mics 15, 564.Petersen BS, Spehlmann ME, Raedler A, Stade B, Thomsen I, Rabionet R, Rosenstiel P, Schreiber S, Franke A. Whole genome and exome sequencing of monozygotic twins discordant for...
The sheer volume of data generated from whole exome sequencing and whole genome sequencing presents a challenge for many researchers faced with the prospect of assembling and analyzing it. Whether you are working with whole genome, whole exome, or other targeted sequencing data, the resulting ...
Whole exome and whole genome sequencing. Bick, David,Dimmock, David - 《Current Opinion in Pediatrics》 - 2011 - 被引量: 281 Screening the human exome: a comparison of whole genome and whole transcriptome se...
Development of new technologies, including whole-genome sequencing (WGS) and whole-exome sequencing (WES), now allows the deciphering of acute leukemia genomes in ever greater detail. WGS and WES have proven their capacity to identify novel, clinically relevant genetic abnormalities (driver mutations...