Whole-genome sequencingWhole-exome sequencingNext-generation sequencingAcute leukemiaAcute myeloid leukemiaAcute lymphoblastic leukemiaAcute leukemia is characterized by abnormal proliferation of hematopoietic cells. Development of new technologies, including whole-genome sequencing (WGS) and whole-exome sequencing...
In the global whole genome and exome sequencing market, as of 2023, the kits segment holds the largest share at 62.83%. This dominance can be attributed to the essential role kits play in the sequencing process, en...
Analysis and Annotation of Whole-Genome or Whole-Exome Sequencing-Derived Variants for Clinical Diagnosis. 2013:, 9.24.1-9.24.24. /Worthey, E.A., 2013. Analysis and annotation of whole-genome or whole-exome sequencing-derived variants for clinical diagnosis. Curr. Protoc. Hum. Genet. 79 (...
Whole genome and exome sequencing of monozygotic twins discordant for Crohn's disease. BMC Genomics. 2014; 15:564.Petersen, B. S., Spehlmann, M. E., Raedler, A., Stade, B., Thomsen, I., Rabionet, R., . . . Franke, A. (2014). Whole genome and exome sequencing of monozygotic...
This economic evaluation estimates the cost-effectiveness of whole-genome sequencing compared with whole-exome sequencing and conventional testing in
Research of these determinants has been performed in candidate gene, genome-wide association and linkage studies. Because exploration of the common variation in the genome did not explain much of the variation in the rate of aging and longevity, researchers in the field have only recently started ...
Analysis and annotation of whole-genome or whole-exome sequencing-derived variants for clinical diagnosis. Curr. Protoc. Hum. Genet. 79 (Unit 9 24).Worthey EA. 2013. Analysis and annotation of whole-genome or whole-exome sequencing-derived variants for clinical diagnosis. In: Current protocols...
Zhiming Cai and colleagues report whole-genome and whole-exome sequencing of 99 paired tumor-normal samples of transitional cell carcinoma of the bladder. They find that 32% of tumors harbor alterations in genes involved in sister chromatid cohesion, inc
genome. However, as sequencing technology rapidly improves and cost per sequenced nucleotide falls, there is likely to come a point where it is more economic to sequence a whole genome rather than target-capture and sequence, even if analysis is confined to just the exome. Where that point ...
Background Concordance between whole genome sequencing (WGS)/whole exome sequencing (WES) and circulating tumor DNA (ctDNA) is not known. Therefore, we studied concordance between matched WGS/WES and ctDNA in various solid tumors. In addition, we carried out an analysis of hotspot and actionabl...