strains. Although whole-genome sequencing (WGS) has the po- tential to capture all genetic variation in a sample, allowing both precise tracking of epidemics and insight regarding the strain’s evolution, it has not been used to characterize S. pneumoniae outbreaks. WGS has been successfully use...
Whole‐Genome Sequencing (WGSBaseSpaceNext‐generation sequencing (NGS) technologies have revolutionized the biosciences and become invaluable to the discovery of gene function and its involvement in disease conditions. The fast pace of innovation in NGS technologies has enabled the production of huge ...
Human population genomic studies, including whole‐genome sequencing, were undertaken to identify determinants of bone mineral density (BMD), a major predictor of osteoporotic fractures. Non‐coding variants with large effects on BMD and fractures were i
Amalio Telenti, Craig Venter and colleagues report common, low-frequency and rare variants associated with blood metabolite levels using whole-genome sequencing and comprehensive metabolite profiling in 1,960 individuals. They identify 246 metabolites wh
Cultivated peanut (Arachis hypogaea L.) is a widely grown oilseed crop worldwide; however, the events leading to its origin and diversification are not fully understood. Here by combining chloroplast and whole-genome sequence data from a large germplasm
The cost of Whole Genome Sequencing (WGS) has decreased tremendously in recent years due to advances in next-generation sequencing technologies. Nevertheless, the cost of carrying out large-scale cohort studies using WGS is still daunting. Past simulation studies with coverage at ~2x have shown pro...
Currently next generation sequencing facilitates SNP discovery and allows deeper analysis of genome variation [1, 2]. In plants, SNP discovery has been performed either from RNA-Seq experiments [3, 4] or whole genome resequencing. Millions of polymorphisms have thus been discovered in Arabidopsis [...
Whole-Genome Chromatin IP Sequencing (ChIP-Seq)Illumina ChIP-Seq combines chromatin immunoprecipitation (ChIP) with massively parallel DNA sequencing to identify binding sites of DNA-associated proteins. Illumina ChIP-Seq technology precisely and cost-effectively maps global binding sites for a protein ...
Genome sequencing and functional annotation provide valuable information for efforts to determine the potential function and gene expression mechanisms, which can provide the theoretical basis for cultivation and breeding of R. griseocarnos. To the best of our knowledge, this whole genome de novo ...
Whole genome sequencing Auricularia heimuer Edible-medicinal fungus Secondary metabolism 1. Introduction Auricularia is a very important genus of wood-decaying fungi, and several species are widely cultivated as edible and medicinal mushrooms in China and some other Asian countries. Among them, Heimuer,...