Whole genome sequencing (WGS) has the potential to be a comprehensive genetic test, especially relevant for individuals with neurodevelopmental disorders, syndromes and congenital malformations. However, the cost consequences of using whole genome sequencing as a first-line genetic test for these ...
Whole genome sequencing (WGS) of Mycobacterium tuberculosis has rapidly progressed from a research tool to a clinical application for the diagnosis and management of tuberculosis and in public health surveillance. This development has been facilitated by drastic drops in cost, advances in technology and...
Whole-genome sequencing (WGS) is becoming a fast and cost-effective method to pinpoint molecular lesions in mutagenized genetic model systems, such as Caen... M Doitsidou,RJ Poole,S Sarin,... - 《Plos One》 被引量: 258发表: 2010年 Accurate whole-genome sequencing and haplotyping from 10...
Whole-genome sequencing is suitable for the study of disease-specific genomic abnormalities from cfDNA. TheInvitrogen Collibri PS DNA Library Prep Kit for Illumina Systemsenables consistent and reproducible cfDNA library prepa...
Recent advances in genomics and bioinformatics, allied with reductions in the cost of next-generation sequencing, has facilitated the development of precision medicine programmes and allowed increasing numbers of solid tumours to undergo rapid whole-genome sequencing (WGS). Whilst the primary focus of ...
The cost of Whole Genome Sequencing (WGS) has decreased tremendously in recent years due to advances in next-generation sequencing technologies. Nevertheless, the cost of carrying out large-scale cohort studies using WGS is still daunting. Past simulation studies with coverage at ~2x have shown pro...
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The sphere of medical genetics has also greatly leveraged the cost-effective nature ofwhole-genome sequencing. WGS is increasingly being employed in deciphering the genetic underpinnings of Mendelian as well as complex diseases, illuminating novel disease biology, and providing substantial assistance in cl...
Among the different genome-wide DNA methylation technologies, whole genome bisulphite sequencing (WGBS) is considered the gold standard for assaying genome-wide DNA methylation at single base resolution. However, the high sequencing cost to achieve the optimal depth of coverage limits its application ...
Whole genome sequencing (WGS) improves Mendelian disorder diagnosis over whole exome sequencing (WES); however, additional diagnostic yields and costs remain undefined. We investigated differences between diagnostic and cost outcomes of WGS and WES in a cohort with suspected Mendelian disorders. WGS was...