Whole genome sequencingInformed consentPatient-doctor relationshipRecontactingScreeningBlurring boundariesResearch ethicsNew developments in genetics and genomics offer a constant challenge to ethical reflection. One such development is the application of whole genome sequencing (WGS) as a diagnostic tool. The...
We examined the feasibility of using whole-genome sequencing (WGS) data to design tumour-specific polymerase chain reaction (PCR)-based MRD tests (WGS-MRD) in 18 children with high-risk relapsed cancer, including ALL, high-risk neuroblastoma (HR-NB) and Ewing sarcoma (EWS) (n = 6 eac...
Here, we provide a case report describing the diagnosis and treatment of a man with primary M1 oligometastatic PC who volunteered to release his entire protected health information, including the results of whole-genome sequencing (WGS) of his germline and both whole-exome sequencing (WES) and W...
8,9. Whole-genome sequencing (WGS) is a powerful technology for investigations of alterations in intronic and intergenic regions as well as in the exome, and provides an opportunity to delineate the complete MSs imprinted
whole genome sequencing (WGS) a valuable source of information in many clinical situations. Compared to other genomic analysis, archived WGS data moreover have the potential to serve as a lifelong companion for patients that can be reanalysed and reinterpreted several times along the patient journey...
We wonder if the notion of WGS needs clarification when used in discussions with patients. Although each donated DNA sample may have full genome sequencing, it is important for the clinician to explain that only specific segments of the genome, pertaining to the clinical phenotype, will be analyz...
Whole-genome sequencing provides unique information not available from prior studies with whole-exome sequencing, including data on translocations, complex rearrangements and genome-wide mutational patterns. However, relatively higher sequencing costs have limited the number of whole-genome studies (n=4, ...
We performed whole-genome sequencing (WGS) on 40 pairs of primary and recurrent hepatitis B virus (HBV)-related HCC tumors obtained at primary diagnosis and at the time of early recurrence after curative resection. We compared the genetic profiles of the primary and early-recurrent tumors to det...
Whole genome sequencing (WGS) is a technology able to provide all this information in a single approach.Niroshan NadarajahMolecular Med TRI-CON/Bio-IT WEST 2019
Whole genome sequencing (WGS) with paired germline tissue can be used to reconstruct the evolutionary “life history” of breast tumors, providing a detailed roadmap for early or late clonal and subclonal genomic events that help prioritize therapeutic targets12,13,14. To date, however, the evol...