October 25, 2023 Paints & Coatings Specialty Exterior Portfolio offers products with superior performance for multiple substrates Read More October 25, 2023 Printing & Packaging Simon Says: Tales from the road, packaging observations in Asia Simon reflects on three weeks spent observing the market...
In addition, mutation of both of the aspartyl residues does not completely suppress Aβ production, although it does cause accumulation of the substrates for γ-secretase cleavage (raising the possibility that PS1 is involved in trafficking substrates to or adapting substrates for the γ-secretase)....
an acrylamide, was appended to a reversible inhibitor. The primary reason for doing this was to disconnect the pharmacokinetics and pharmacodynamic parameters for a particular series and to compete with high intracellular concentrations of endogenous substrates such as ATP [13]. This led to the ...
enzyme (CAZymes) for cleaving linkage type and associated protein i.e. carbohydrate-linkage protein and transporters (Hamaker and Tuncil, 2014). It is noteworthy that bacteria degrade carbohydrate-based substrates in a highly competitive milieu, their ability to compete depends upon the presence of...
and are intended to be reapplied periodically as a preventive maintenance treatment. This aspect emphasizes the frequent and intensive use of these products, which may lead to an accumulation of potentially toxic substances for the operators that have to be in contact with the substrates of treated...
Lastly, generation of EpICD by γ-secretase is a particularly slow process with a 50% turnover of EpCAM-CTF between 0.75 and 5.5 h [152], as shown for other γ-secretase substrates [153]. Furthermore, EpICD is a highly labile protein that is degraded by the proteasome [34, 152], ...
October 25, 2023 Paints & Coatings Specialty Exterior Portfolio offers products with superior performance for multiple substrates Read More October 25, 2023 Printing & Packaging Simon Says: Tales from the road, packaging observations in Asia Simon reflects on three weeks spent observing the market...