The regulatory roles of ZFAND proteins appear to be important not only for the control of protein degradation but also for other cellular processes, such as mRNA stability and signaling pathways. This review summarizes the known functions of proteasome activators and discusses their possible roles in...
Large chromosomal deletions, such as del(5q) and del(7q), that occur in t-MN do not harbour a single, recessive tumour suppressor gene but instead are part of a contiguous gene syndrome (CGS). Moreover, the genes involved in CGSs on these chromosomes act by haploinsufficiency. An aberran...
How does splicing of pre-mRNA occur? What is RNA splicing? Which strand of DNA is used to make mRNA? What mRNA codon starts the making of a protein? Where does the mRNA get transcribed? How do I transcribe DNA to mRNA and mRNA to protein?
The consumption of nuts does not result in a higher body weight; possible energy regulatory mechanisms include a decrease in subsequent energy intake and an increase in energy expenditure. This research aimed to explore how tree nut and peanut consumption affected energy intake, compensation, and exp...
Wlds mouse is a strain in which severed peripheral nerves do not degenerate for several weeks, and axonal regeneration does not occur either [5, 11]. In this strain, we studied the role of resident cells upon axonal regeneration by inhibiting transcription. Regeneration was assessed with the ...
Here we discuss recent findings on how actively dividing cells cope with endogenous genomic lesions that occur frequently at repetitive, heterochromatic, and late replicating regions as byproducts of genome duplication. We discuss how such lesions, rather than being resolved immediately when they occur,...
It is currently unclear as to whether sex hormones are significantly affected by soy or whey protein consumption. Additionally, estrogenic signaling may be potentiated via soy protein supplementation due to the presence of phytoestrogenic isoflavones. Limited evidence suggests that whey protein supplementati...
Because the only difference between two free chains and two colliding chains is the presence of a contact point, the splitting reaction must occur at the contact point. The lifetime of the ‘contact state’ must be on the order of the chain relaxation time, which is in the millisecond time...
How does ATP interact with a protein which is acting as an enzyme? A) ATP generates protein B) It changes the shape of the protein(enzyme) so that a chemical reaction may occur C) ATP does not interact with protein D) ATP diffuses through protein E) A...
The RNA-SIP protocol (Whiteley et al., 2007) focusses on 16S rRNA and does not capture mRNA. There is no questioning the value of retrieving expressed genes (that is, mRNA) or synthesized polypeptides from the environment, which are involved in growth on a particular compound. Once these ...