20220223-Cell Biology-Golgi and lysosome and protein degradation是细胞生物学的第6集视频,该合集共计16集,视频收藏或关注UP主,及时了解更多相关视频内容。
Protein degradation unlocked. (Cell Biology).(research; includes quality control chart)The endoplasmic reticulum (ER) of the cell operates a quality control system that identifies misfolded proteins, transports them into the cytoplasm and then targets them for degradation by the protea-some. Aberrant ...
广州医科大学附属第三医院生殖医学中心李磊副研究员团队与南方医科大学基础医学院李琳教授团队合作在《Nature Cell Biology》上发表题为“Single-cell multi-omics profiling of human preimplantation embryos identifies cytoskeletal defects during embryonic arrest”的研究论文。 不孕症的一个常见原因是人类胚胎发育受阻,然...
惰性癌细胞可形成纤连蛋白纤丝而激活integrin介导的信号通路,以保证癌细胞在该部位的定植和存活。深入研究发现,肺部表皮细胞通过激活癌细胞中的secreted frizzled-related protein 2(SFRP2)蛋白来促进细胞形成纤丝系统,进而促进癌细胞存活。而阻断SFRP2蛋白可有效地减少惰性癌细胞数目。 原文链接: https://doi.org/10...
M. PROTAC targeted protein degraders: the past is prologue. Nat. Rev. Drug Discov. 21, 181–200 (2022). Article CAS PubMed PubMed Central Google Scholar Wu, T. et al. Targeted protein degradation as a powerful research tool in basic biology and drug target discovery. Nat. Struct. ...
近日，来自德国慕尼黑大学基因中心的Julian Stingele 研究团队和英国癌症中心的Stephen P. Jackson研究团队合作在Nature Cell Biology杂志上发表题为Transcription-coupled repair ofDNA–protein cross-links depends on CSA and CSB的研究论文，该研究发现了CSA和CSB（ Cockayne syndrome (CS) proteins）在介导DNA -...
这篇文章2020年10月发表于Nature Cell Biology（IF=21.3，SIRT1 is downregulated by autophagy in senescence and ageing，至今总引用为163次），是一篇寻找衰老调控蛋白SIRT1上游的文章，其关于基因表达调控机制，尤其是蛋白的翻译后调控机制的研究思路非常具有代表性，正在做或者准备做相关方向的同学可以借鉴一下。研...
both in cultured cells and mouse liver or expression of CMA-resistant PLINs leads to reduced association of ATGL and macrolipophagy-related proteins with LDs and the subsequent decrease in lipid oxidation and accumulation of LDs. We propose a role for CMA in LD biology and in the maintenance ...
Cell biology articles within Nature Communications Featured Article 08 June 2024 | Open Access The TAS1R2 G-protein-coupled receptor is an ambient glucose sensor in skeletal muscle that regulates NAD homeostasis and mitochondrial capacity The bioavailability of NAD is vital for muscle health. ...
A. A little sugar goes a long way: the cell biology of O-GlcNAc. J. Cell Biol. 208, 869–880 (2015). Article CAS PubMed PubMed Central Google Scholar Levine, Z. G. & Walker, S. The biochemistry of O-GlcNAc transferase: which functions make it essential in mammalian cells? Annu...