protein degradationSREBPSterol regulatory element-binding proteins (SREBPs) are transcription factors that regulate the expression of genes involved in fatty acid and cholesterol biosynthetic pathways. The present study showed that the flavonoid chrysin impairs the fatty acid synthase promoter. Chrysin ...
Scrapie and chronic wasting disease (CWD) are prion diseases of particular environmental concern as they are horizontally transmissible and can remain infectious after years in the environment. Recent evidence suggests that the N-terminus of PrP, the infectious conformation of the prion protein, plays...
CPG2: a brain- and synapse-specific protein that regulates the endocytosis of glutamate receptors. Neuron 44: 677–690. CAS PubMed PubMed Central Google Scholar Coyle JT, Tsai G (2004). NMDA receptor function, neuroplasticity, and the pathophysiology of schizophrenia. Int Rev Neurobiol 59: ...
Another transmembrane protein, Advanced Glycation Endproduct Receptor 1 (AGER1), mediates the uptake, degradation and disposal of AGEs and has been involved in cell survival and regulation of reactive oxygen species30. AGER1 is encoded by the gene DDOST and demonstrates an antagonistic effect to fu...
A formulation scientist assigned the task of developing a stable, elegant, and manufacturable dosage form of a therapeutic protein drug has been given a significant challenge. Most proteins, as natural physiological molecules, are inherently unstable outside the human or animal body. Stability challenge...
Recently, in Sudanese families with GGE, we reported rare missense variants ofADGRV1gene [14], encoding the adhesion G protein–coupled receptor V1 [15]. While loss of function variants inADGRV1are responsible for the rare autosomal recessive Usher IIC syndrome, the homozygous c.6835delG (...
2005. p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death. J. Cell Biol. 171:603-... A Yamamoto,A Simonsen - 《Autophagy》 被引量: 0发表: 2011年 p62/SQSTM1 Binds Directly to Atg8/LC3 to Facilitate Degradation of Ubiqui...
suggest that protein ubiquitination is one of the causes of cell death. Almagro identified that the ubiquitination and phosphorylation of RIP1 are coordinated and interdependent, which irritates necroptotic signaling and cell death [58]. Hence, copper could promote cell death via protein degradation....
transfected cells (Supplementary Fig.2). We also found that cells with abnormal Lamin A/C staining were characterized by reduced nuclear levels of the protein (Fig.2c) but no increase in cytoplasmic levels (Supplementary Fig.S4), suggesting that Lamin A/C may be targeted for degradation as ...
We report our findings on the assembly of the HIV-1 protein Vpu into soluble oligomers. Vpu is a key HIV-1 protein. It has been considered exclusively a single-pass membrane protein. Previous observations show that this protein forms stable oligomers in