In subject area: Biochemistry, Genetics and Molecular Biology Featured on this page Chapters and Articles You might find these chapters and articles relevant to this topic. Intrinsic protein instability : deamidation Yutong Jin, ... Bernice Yeung, in ...
4A), our data argue that ubiquitin-mediated protein degradation may be a bona fide factor behind the negative correlation between intrinsic disorder and overall expression propensity observed in the eukaryotic expression system in this study. Notably, only a little increase of a low statistical ...
Particulate matter (PM) modulates the expression of autophagy; however, the role of selective autophagy by PM remains unclear. The objective of this study was to determine the underlying mechanisms in protein oxidation and degradation caused by PM. Human epithelial A549 cells were exposed to diesel...
ER associated protein degradation is a process detecting misfolded proteins in the ER and redirecting them to the translocon for retranslocation to the cytosol, where they are subjected to proteasomal degradation. Additionally, excess subunits of multimeric proteins that are unable to assemble are degrad...
A. degradation of the second messenger B. desensitization of receptors C. deactivation of a signal transduction protein D. all of the above 正确答案:D 5 单选 Which of the following does not exist? A. Protein Kinase A B. Protein Kinase B C. 元气小课堂 15/37 元气小课堂 Phospholipase ...
removal. protein degradation is executed by linking the misfolded protein to ubiquitin after it has been re-translocated into the cytosol through the same er translocon pore where it had been imported. the ubiquitin-marked protein is then recognized and degraded by the 26s proteasome in the ...
Proteolysis-targeting chimeras (PROTACs) represent a new therapeutic modality involving selectively directing disease-causing proteins for degradation through proteolytic systems. Our ability to exploit targeted protein degradation (TPD) for antibiotic d
Protein degradation via three distinct lysosome pathways. (1) Cell surface proteins arrive at endosome after endocytosis. They could be degraded by lysosome, or transported to the plasma membrane or other cellular organelles for recycling. (2) In the phagocytic pathway, cells engulf large extracellula...
Molecular glues, on the other hand, are low-molecular-weight inducers of protein-protein interactions that, by binding to one interaction partner, create “neo-surfaces” allowing the other interaction partner to bind (Figure 1). In the context of UPS-mediated targeted protein degradation, the pl...
E6-mediated p53 degradation prevents the normal repair of chance mutations in the cellular genome. The E7 product (~100aa) has similar effects. E 64 An inhibitor of most cysteine peptidases in clan CA and some other peptidases but not a general inhibitor of cysteine peptidases. EA-rosettes ...