“Several research groups are now working together to investigate what effect this may have on the DNA molecule. We already know that R-loop regions are associated with DNA sequences that contain active genes, and that this can lead to chromosome breaks and the loss of genetic information.” ...
In the case of COVID-19 shots, he says, “The concern is if this DNA integrates the genome, one portion of the SSV40 sequence is an SV40 promoter, a very strong promoter, which means it drives transcription wherever it lands in the genome. If this happens to drop itself in front of ...
Transcribe the given DNA sequence to mRNA: 5'-CCGTATG-3'. Give an mRNA sequence that will code for the synthesis of metenkephalin. Tyr-Gly-Gly-Phe-Met What is the minimum number of single-nucleotide substitutions that would be necessary for the amino a...
Expression of a β-globin gene is enhanced by remote SV40 DNA sequences. Cell 27, 299–308 (1981). Article CAS PubMed Google Scholar Neuberger, M.S. Expression and regulation of immunoglobulin heavy chain gene transfected into lymphoid cells. EMBO J. 2, 1373–1378 (1983). Article CAS ...
What is a segmented RNA virus? Is calicivirus a retrovirus? What is unique about each person's DNA structure? What are the disadvantages of retrovirus vectors? How unique is any DNA sequence? What is a template in DNA replication? Is a retrovirus safer than a lentivirus? What are some exam...
The gene products that regulate MDM-2 (and p53) levels and activities will need to be better characterized. The MDM-X (or MDM-4) gene was identified because it is related to the MDM-2 gene in its DNA and protein sequence. A knockout of the MDM-X gene in mice is lethal and a MDM...
Most people believe that the origin of HIV, the AIDS virus, derives from some natural evolutionary event. Key among these HIV origin theories is the so called “cut hunter theory” in which a human, allegedly African native, received a bloody wound or in
The etiology of childhood cancers has been studied for more than 40 years. However, most if not all cancers occurring in children are attributed to unknown causes. This review is focused on the role of infections in cancer development and progression in children. The main infectious agents includ...
SV40 promoterIn the article above, we present arguments in favor of complete genome sequencing as an important research tool. In the following article by Branscomb and Predki (J. Bacteriol. 184.6406-6409, 2002) about draft microbial genome sequence data, the authors raise the notion that "...
As mentioned above, PLCγ1 is the main PLC isozyme whereby growth factors, such as VEGF, the master regulator of angiogenesis, regulate endothelial cell proliferation, migration, and tube formation [58,59,68]. For instance, targeted next generation sequence recently identified a PLCγ1 with a ...