MAPK signaling pathway and endometriosis: what is the link? [J]. Arch Gynecol Obstet , 2013, 287 ( 4 ) : 837 - 838.Mormile,R.,Vittori,G.. MAPK signaling pathway and endometriosis: What is the link?[J].Archives of gynecology and obstetrics 2013,4(4)....
(MKK7) were downregulated in endometriosis stromal cells, suggesting the involvement of the RAS/RAF/MAPK signaling pathway through PDGFRA in endometriosis ... S Matsuzaki,M Canis,C Vaurs-Barrière,... - 《Molecular Human Reproduction》 被引量: 268发表: 2004年 Alterations in mitogen-activated pro...
In the present paper, we review recent advances in our understanding of IE gene transcription, chiefly focusing on FOS and its activation by ERK (extracellular-signal-regulated kinase) MAPK (mitogen-activated protein kinase) pathway signalling. We highlight important fundamental regulatory principles, ...
eukaryotic gene regulation: \\ Transcription factors are sometimes activated by phosphorylation as in the MAPK pathway. Explain how this links an extracellular hormone signal to eukaryotic gene transcription. Be specific. Which transcription factor becomes translocated to the nucleus downstream of calmodulin...
A RASopathy is a medical genetic syndrome that is caused by germline mutations in genes that encode components or regulators of the well-studied oncogenic RAS/mitogen-activated protein kinase (MAPK) signal transduction pathway. These syndromes include neurofibromatosis type-1, Noonan syndrome, Noonan sy...
Although first results with BRAF inhibitors as single agents in BRAF-mutated CRC were disappointing, their association with therapies targeting the MAPK pathway seems to overcome the primary resistance to BRAF inhibition. In the field of sporadic CRC, the BRAF mutation is strongly associated with MMR...
• PI3K/AKT, MAPK, JAK-STAT, and RAP1 pathway receptors are enriched on the CHO cell surface and downstream pathways present on mRNA level. • Detected pathways indicate strong CHO survival and growth phenotypes. • Potential self-induction of surface receptors and respective ligands. Graphica...
Because polypeptidehormones are not fat-soluble, they cannot penetrate cell membranes. Thus, GH exerts some of its effects by binding to receptors on target cells, where it activates the MAPK/ERK pathway. Through this mechanism GH directly stimulates division and multiplication of chondrocytesof carti...
Mutation analysis of the Ras pathway genes NRAS, HRAS, KRAS and BRAF in glioblastomas Aberrant activation of Ras signaling is a common finding in human glioblastomas. To determine the contribution of Ras gene mutations to this aberration, we... CB Knobbe,J Reifenberger,G Reifenberger - 《Acta...
In oocyte maturation, the Mos-MAPK pathway probably serves to activate and stabilize M-phase promoting factor (MPF) (possibly by inhibiting some negative regulator(s) of this factor), while in cellular transformation, it seems to stabilize and activate the nuclear oncoprotein c-Fos as well as ...