Importantly, the same phenotypic outcome could be achieved by several different combinations of genetic perturbations in both pathways (e.g., A-X, A-Z, B-X, B-Y, B-Z) (Fig.1b). This model for the local topology of genetic networks, called the “between-pathway model” (BPM), has ...
Consistent with this latter proposition, MKK6 and p38β were found to be upregulated during the course of osteoblast differentiation. To prove that the p38 MAPK pathway is involved in mediating the effect of TAK1 to promote osteoblast differentiation, the authors expressed either a constitutively ...
Regulation of the G 2 – M cell cycle progression by the ERK 5 – NF κ B signaling pathway The extracellular signal–regulated kinase (ERK) 5 is a member of the MAPKs (Lee et al., 1995; Zhou et al., 1995). The Nterminal kinase domain of ERK5 is h... K Cude,Y Wang,H Choi...
A closer look at these genes allows us to observe the existence of a significant number related to the MAP kinase signaling pathway. The MAPK cascade is related to various cellular processes: the pheromone response pathway, filamentous invasive growth, hyperosmotic response and cell wall remodeling....
Guvakova MA, Surmacz E. Tamoxifen interferes with the insulin-like growth factor I receptor (IGF-IR) signaling pathway in breast cancer cells.Cancer Res1997;57:2606–2610. PubMedCASGoogle Scholar Resnik JL, Reichart DB, Huey K, et al. Elevated insulin-like growth factor I receptor autophos...
We identified 34 differentially expressed genes (DEGs) of depression from OC patients. Gene ontology (GO) and KEGG pathway analyses indicated several molecular pathways including complement and coagulation cascades, the Hippo signaling pathway, ether lipid metabolism, the MAPK signaling pathway, and ...
P38α MAPKprostate cancervirtual screeningAim: P38α?plays a crucial role in the development of castration-resistant prostate cancer. Discovering novel inhibitors of P38α offers potential for the development of new anticancer drugs. Methodsandresults: Compounds from the Chemdiv and Enamine virtual ...
Seven pieces of meaningful matching information for the three proteins were obtained from database searching. CONCLUSION: Biomarkers with m/z 4229,8162 and 9084 are ERK1/2 phosphorylation dependent,and therefore are the downstream molecules of ERK1/2 in the ERK/MAPK signaling pathway. The three ...
in Merkel Cell CarcinomaRAS/RAF/MAPKThe secreted Wingless type (Wnt) pathwayVEGF and related proteinsMatrix metalloproteinases RAS/RAF/MAPK The secreted Wingless type (Wnt) pathway VEGF and related proteins Matrix metalloproteinases Clinical Implications of Genomic Approaches to Merkel Cell Carcinoma ...
Enrichment analysisshowed that the biological process of hub targets included transcriptional regulation, cell proliferation,redox processes, apoptosis processes, ERK1 and ERK2 cascades, hypoxia reactions, MAPK cascades,and inflammatory responses. The main signalling pathways included HIF, TNF, and PI3K-...