This mini-review focuses only on the role of the complement system in AD. Alzheimer’s disease (AD) is a chronic neurodegenerative disorder with characterization by extracellular senile plaques, intracellular neurofibrillary tangles and neuronal loss[11–15]. The major component of senile plaques is ...
(f ) 'major failure' as referred to in clause 10 of this warranty has the same meaning referred to in the ACL and includes a situation when an Appliance cannot be repaired or it is uneconomic for Residentia Group, at its discretion, to repair an Appliance during the Warranty Period; (...
The major incidents referred to in the latter context are the wars and conflicts that occurred after his migration to Medina. These conflicts are also prominent in s¯ırah narratives of his Medinan life from classical and modern periods. One can argue that there is a significant difference...
While ensuring recipient safety is a priority above all, research on optimal donor selection beyond the exclusion of transmissible pathogens is still at an early stage [15,19]. Although the choice of donor does not influence the efficacy of FMT to treat Clostridium difficile infections (currently ...
Figure 1 illustrates such CPP-assisted strategies in achieving intracellular delivery of the drug payloads. 2.1. Covalent Conjugation of Therapeutic Agents with CPP The commonly used strategy for CPP-assisted drug delivery is by covalent conjugation, either chemically or biologically, of CPPs with the...
For instance, in Bangladesh, with seventy percent of the population living in flood prone low-land regions, diarrhea is the major illness cause, which accounted for thirty-five percent of the 45.000 hospital admissions and twenty-seven percent of 154 reported deaths [23]. The most common ...
Strong evidence has proved the importance of this group of molecules in the gastrointestinal context, also playing roles in several pathologies. This work is based on the hypothesis that integration of biomedical information helps to reach new translational actions. Thus, the major aim of this work...
The functional activity is revealed by a flow of physiologically relevant inorganic ions, such as Na+, K+ and Cl−, across the BLM either from cyclic voltammetry (current-voltage curves in biophysical jargon) or chronoamperometry measurements (current-time curves) [3]. A major drawback of ...
Traditionally, the major stress-inducible HSP70s comprise Hsp70-1 (HspA1A) and Hsp70-2 (HspA1B), collectively termed Hsp70 or Hsp70-1, and these differ only by two amino acids [41]. In unstressed conditions, heat shock transcription factor (HSF-1) is maintained in its monomer form, ...
In the next sections below we discuss the current state of knowledge on a particular family of pore-forming proteins, namely, the RTX pore-forming toxin family, which is as large as it is unknown in many aspects. We also summarize recent information from our own laboratory on pore formation...