Kinoshita T (1994) The genetic defect of PNH. Clin Exp Immunol 97: 3–4. View ArticleKinoshita T. The genetic defect ofPNH. Clin Exp Immuno11994: 97 Suppl2: 3.T.KINOSHITA. (1994) The genetic defect of PNH. Clinical & Experimental Immunology 97 :10.1111/cei.1994.97.issue-s2, 3-4 /...
P. GPI-anchored complement regulatory proteins in seminal plasma. An analysis of their physical condition and the mechanisms of their binding to exogenous cells. J. Clin. Invest. 97, 1675–1686 (1996). Article CAS Google Scholar Sloand, E. M. et al. Correction of the PNH defect by GPI...
Impaired hematopoiesis in paroxysmal nocturnal hemoglobinuria/aplastic anemia is not associated with a selective proliferative defect in the glycosylphosph... Paroxysmal nocturnal hemoglobinuria (PNH) results from somatic mutations in the PIG-A gene, leading to poor presentation of glycosylphosphatidylinositol...
Hemolytic anemia may be further classified as inherited or acquired, immune or nonimmune, acute or chronic, whether hemolysis occurs in the vasculature (intravascular) or the reticuloendothelial system (extravascular), and whether there is a cellular defect of the erythrocyte (intrinsic) or ...
(Botany) a mutation occurring in a somatic cell, resulting in a change in the morphology or some other aspect of one part of an organism (usually a plant). It may be maintained by vegetative propagation but not by sexual reproduction ...
Affected erythrocytes of patients with paroxysmal nocturnal hemoglobinuria are deficient in the complement regulatory protein, decay accelerating factor Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired defect of bone marrow stem cells in which the affected clones produce erythrocytes (also granulocy....
PIGA catalyzes the first step in GPI biosynthesis and it is anticipated that even a partial defect in activity will have a significant impact on the localization and functionality of a broad range of GPI-anchored proteins. The elevation in serum alkaline phosphatase reported here as well as in ...
Thus, the Inab phenotype appears to represent an instance of hereditary erythrocyte DAF deficiency whose mechanism differs from that of paroxysmal nocturnal hemoglobinuria (PNH) and which is unassociated with clinically evident hemolytic disease.
GPI-anchorless PrP was also found on blood cells of patients with paroxysmal nocturnal hemoglobinuria suffering from the clonal defect in GPI synthesis [22, 23]. However, in their affected cells the protein seems to be expressed intracellularly, likely in a transmembrane form [23] and patients ...
RNA cargo is predominantly comprised of 5S rRNA, regardless of stimulation; however, CD24 causes a decrease in the incorporation of protein coding transcripts. The MV proteome is enriched with mitochondrial and metabolism-related proteins after CD24 stimulation; however, these changes were variable ...