(1994) Paroxysmal nocturnal haemoglobinuria (PNH) is caused by somatic mutations in the PIG-A gene. EMBO J. 13, 110-117.Bessler M, Mason PJ, Hillmen P, et al. Paroxysmal nocturnal haemo- globinuria (PNH) is caused by somatic mutations in the PIG-A gene. EMBO J. 1994;13:110-117...
Paroxysmal nocturnal hemoglobinuria (PNH) is caused by phosphatidylinositol glycan-class A (PIG-A) mutations in hematopoietic stem cells (HSCs). PIG-A muta... R Hu,GL Mukhina,S Piantadosi,... - 《Blood》 被引量: 229发表: 2005年 The phenotype of a germline mutation in PIGA: the gene so...
Paroxysmal nocturnal haemoglobinuria is caused by a somatic mutation, meaning a genetic alteration that occurs in a cell and is passed to the progeny of the mutated cell during cell division. So PNH is an acquired genetic disorder. It is not an inherited genetic alteration, but a somatic mutat...
uncommon acquired stem cell disorder associated with periodic hemolytic events. This benign clonal disease is caused by abnormalities of the X-linked phosphatidylinositol glycan class A (PIGA) gene and is associated with cytopenias and thrombosis.Although the trilineage of bone marrow elements is ...
一男性患者因心脏疾病前来就诊，吕医生在接诊后初步进行心脏叩诊检查，一边要求患者平躺在床上并暴露胸部，叩诊过程中一边用笔进行标记，患者表示不解，遂询问为什么要在自己身上画标记，这时吕医生应如何回答较妥当？（ ）
Paroxysmal nocturnal hemoglobinuria (PNH) is an uncommon acquired stem cell disorder associated with periodic hemolytic events. This benign clonal disease is caused by abnormalities of the Xlinked phosphatidylinositol glycan class A (PIGA) gene and is associated with cytopenias and thrombosis. Although ...
In both cases, der(12) had a break within the 3′ untranslated region of HMGA2, the architectural transcription factor gene deregulated in many benign mesenchymal tumors, that caused ectopic expression of HMGA2 in the bone marrow. These observations suggest that aberrant HMGA2 expression, in ...
每日一词:Stroke 中风、脑卒中。世界卫生组织这样介绍中风:A stroke is caused by the interruption of the blood supply to the brain, usually because a blood vessel bursts or is blocked by a clot. This cuts off the supply of oxygen and nutrients, causing damage to the brain tissue. ...
Error: require(...).internalModuleStat is not a function This error can be caused by usingNODE_OPTIONSvariable with some bootstrap ornodeoptions causing conflicts withpkg. Some IDEs, such asVS Code, may add this env variable automatically. ...
The pump plunger sealing system is adopted in the pump, which can effectively prevent the damage caused by water leakage and prevent the pump failure caused by the plunger friction overheating. Such a sealing system is adopted in the water pump, which effectively ...