The presence of a paroxysmal nocturnal hemoglobinuria (PNH) clone points toward an immune pathogenesis, but it is not required. Despite the growing popularity of molecular panels, these findings should not be applied in isolation in decision-making given their lack of prognostic or predictive value ...
After a median follow-up of 3.2 years, the study showed a significant reduction in homocysteine levels, but failed to reach its primary end-point, reduction of all-cause mortality, and its secondary end-point, reduction in cardiovascular death, amputation and thrombosis of the vascular access. ...