Cell Communication and Signaling (2023) 21:96 https://doi.org/10.1186/s12964-023-01125-0 Cell Communication and Signaling REVIEW Open Access What is new in cancer‑associated fibroblast biomarkers? Zehua Zhao1, Tianming Li1, Yuan Yuan2,3,4* and Yanmei Zhu1* Abstract...
It is also important to exclude the presence of other cancers associated with a KRAS mutation (in particular colon or pancreatic adenocarcinomas), which can release mutated somatic DNA into the blood [198,199,200,201]. Mutations in KRAS are often associated with an increase in the expression ...
Complement 5a Enhances Hepatic Metastases of Colon Cancer via Monocyte Chemoattractant Protein-1-mediated Inflammatory Cell Infiltration. J. Biol. Chem. 2015, 290, 10667–10676. [Google Scholar] [CrossRef] Cho, M.S.; Vasquez, H.G.; Rupaimoole, R.; Pradeep, S.; Wu, S.; Zand, B.; ...
KRAS tumor mutations were detected in about 35% of patients; about 65% of patients had KRAS wild type tumors. KRAS mutation in colon ca blocks Cetuximab ELI-002 is an "AMP KRAS vaccine" containing seven Amphiphile mKRAS peptides and a proprietary Amphiphile adjuvant, administered subcutaneously....
cancer (CAC) or IBD-associated cancer in literature. In this type of colorectal cancer, chronic inflammation is main cause of tumorigenesis and has significant differences with other types of colorectal cancer. In CAC mutation inAPCgene is not very common and its occurring is in latter stages. ...
cancer (CAC) or IBD-associated cancer in literature. In this type of colorectal cancer, chronic inflammation is main cause of tumorigenesis and has significant differences with other types of colorectal cancer. In CAC mutation inAPCgene is not very common and its occurring is in latter stages. ...
[40] showed that BRAF mutation is associated with MSI-H in metastatic CRC patients with advanced BRAF mutation,but BRAF mutation is a bad factor. According to the article of Carr et al. [41], lifestyle can affect the molecular pathological types of colorectal cancer and statistics show that...
13,14 In sporadic pancreatic NETs, germline mutations in the DNA repair genes, such as adenine DNA glycosylase activity of 14 human MutY homolog (MUTYH), cell cycle checkpoint kinase 2 (CHEK2), and breast cancer type 2 (BRCA2) can also be demonstrated. 15 The mutation profile of ...
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KRAS MutationThe introduction of oxaliplatin as adjuvant treatment for stage III colon cancer in 2004 has been the last practice changing progress in adjuvant treatment for patients with early colon cancer. Since then, many prognostic and predictive biomarkers have been studied, but only DNA mismatch...