Cancer is the leading cause of death worldwide, and its treatment and outcomes have been dramatically revolutionised by targeted therapies. As the most frequently mutated oncogene, Kirsten rat sarcoma viral oncogene homologue (KRAS) has attracted substantial attention. The understanding ...
2025年2月13日,武汉大学中南医院医学研究院/生命科学学院钟波教授与武汉大学人民医院林丹丹教授课题组合作在Dev Cell上发表了题为KRAS4B oncogenic mutants promote non-small cell lung cancer progression via the interaction of deubiqui...
2. Haigis, K.M. (2017). KRAS Alleles: The Devil Is in the Detail.Trends Cancer3, 686-697. 10.1016/j.trecan.2017.08.006. 3. Huang, L., Guo, Z., Wang, F., and Fu, L. (2021). KRAS mutation: from undruggable to druggable in cancer.Signal Transduct Target Ther6, 386. 10.1038/...
KRAS mutation in cancer.aThe frequency of KRAS mutations across tumour types, including the mutation frequency of common sites and the subtype with the highest mutation rate in different tumour types. KRAS mutations are characterised by single-base missense mutations, 98% of which are found at codo...
Lymph-node-targeted, mKRAS-specific amphiphile vaccine in pancreatic and colorectal cancer: the phase 1 AMPLIFY-201 trial. Nat Med. 2024;30(2):531-542. 6. Jänne PA, Riely GJ, Gadgeel SM, et al. Adagrasib in Non-Small-Cell Lung Cancer Harbori...
4. Jänne PA, Riely GJ, Gadgeel SM, et al: Adagrasib in non–small-cell lung cancer harboring a KRASG12C mutation. N Engl J Med 387:120-131, 2022 5. Fakih M G, Salvatore L, Esaki T, et al. Sotorasib plus panitumumab in refractory colorectal cancer with mutated KRAS G12C[...
KRAS 基因突变MUTATION Allele Registry ID:别名: ClinVar ID: 基因突变位点 Ref. Build:GRCh37Ensembl Version:75 Chr.StartStopRef. sVar. Bases 122536236525403737 Transcript ENST00000256078.4 基因序列
[4] Wei Daoyan, Wang Liang, Zuo Xiangsheng, et al. A small molecule with big impact: MRTX1133 targets the KRASG12D mutation in pancreatic cancer. Clin Cancer Res, 2023, undefined: undefined. [5] Prior Ian A, Hood Fiona E, Hartley James L. The Frequency of Ras Mutations in Cancer....
RAF1 contributes to cell proliferation and STAT3 activation in colorectal cancer independently of microsatellite and KRAS status Coralie Dorard Claire Madry Manuela Baccarini ArticleOpen Access5 Apr 2023 Oncogene Ras protein abundance correlates with Ras isoform mutation patterns in cancer Fiona E. ...
Huang, L., Guo, Z., Wang, F., & Fu, L. (2021). KRAS mutation: from undruggable to druggable in cancer. Signal Transduction and Targeted Therapy, 6(1), 386. https://doi.org/10.1038/s41392-021-00780-4 Jančík, S., Drábek, J., Radzioch, D., & Hajdúch, M. (2010). ...