A mutation in the Kirsten rat sarcoma virus transforming protein (KRAS) is the most common genomic driver identified in patients with lung adenocarcinoma. It is a key component of the PI3K and MAPK pathways and is an important regulator of cell proliferation and survival. Tobacco use and ...
KRAS mutation in lung metastases from colorectal cancer: prognostic implications. Cancer medicine. 2016; 5:256-264.Ghidini M, Personeni N, Bozzarelli S, Baretti M, Basso G, Bianchi P, et al. KRAS mutation in lung metastases from colorectal cancer: prognostic implications. Cancer Med. 2016;5...
本研究[1]的数据来源于西班牙肺癌组织(Spanish Lung Cancer Group)的胸部肿瘤登记处(Thoracic Tumors Registry)。截至2023年1月9日,纳入有年龄信息的所有登记在册的肺癌病例,根据诊断时的年龄(<50岁;≥50岁)对纳入病例的特征进行描述性分析,拟合逻辑回归模型,并通过将样本分为<35岁和≥35岁进行额外分析。 本研究共...
Lymph-node-targeted, mKRAS-specific amphiphile vaccine in pancreatic and colorectal cancer: the phase 1 AMPLIFY-201 trial. Nat Med. 2024;30(2):531-542. 6. Jänne PA, Riely GJ, Gadgeel SM, et al. Adagrasib in Non-Small-Cell Lung Cancer Harbori...
Relationship between EGFR and KRAS mutations and prognosis in Chinese patients with non-small cell lung cancer:a mutation analysis with real-time polymeras... Gao J, Chen JQ, Zhang L, Liang ZY: Relationship between EGFR and KRAS mutations and prognosis in Chinese patients with non-small cell ...
Therefore, there may be ethnic and geographical differences in the KRAS mutations of SCLC. As a result, KRAS mutation should not be excluded in SCLC. 展开 关键词: KRAS mutation Small cell lung cancer extrapulmonary small cell carcinoma
In addition, patients with KRAS mutations usually have a poor response to current standard therapy11. There has been an urgent and unmet need to target KRAS mutations in KRAS-driven cancer. Recently, there has been light on the horizon for one specific mutation, KRAS (G12C). With the ...
英文标题:The relationship between different subtypes of KRAS and PD-L1 & tumor mutation burden (TMB) based on next-generation sequencing (NGS) detection in Chinese lung cancer patients 杂志名称:Translational lung cancer research ...
Mutant KRAS (KM), the most common oncogene in lung cancer (LC), regulates fatty acid (FA) metabolism. However, the role of FA in LC tumorigenesis is still not sufficiently characterized. Here, we show that KMLC has a specific lipid profile, with high triacylglycerides and phosphatidylcholine...
Treatment Strategies for KRAS-Mutated Non-Small-Cell Lung Cancer. Cancers (Basel). 2023 Mar 7;15(6):1635. [2] Huang L, Guo Z, Wang F, Fu L. KRAS mutation: from undruggable to druggable in cancer. Signal Transduct Target Ther. 2021 Nov 15;6(1):386. [3] Schulze CJ, et al....